6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:38:22 ]
2,3-Dichloronitrobenzene Name: 2,3-Dichloronitrobenzene EINECS:221-717-7 Molecular Formula:C6H3Cl2NO2 CAS :3209-22-1 Synonyms:3-Nitro-o-dichlorobenzene; 1,2-dichloro-3-nitro-benzen; 2,3-Dichloro-1-nitrobenzene; 1,2-DICHLORO-3-NITROBENZENE; 2,3-DICHLORONITROBENZENE PESTANAL, 250 ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:37:50 ]
LDN193189(DM 3189) is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:34:40 ]
AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Prolonged exposure with AZ20 increases H2AX pan-nuclear staining, indicative of replication ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:30:46 ]
CZC24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay); exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:27:07 ]
RKI-1447 inhibits potently ROCK1 and ROCK2 in a dose-dependent manner with IC50 values of 14.5 nM and 6.2 nM, respectively. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but had no effect on the phosphorylation levels of the ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:23:13 ]
SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively. ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:18:17 ]
UNC2250 is a phosphorylation of endogenous Mer inhibitor with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:15:28 ]
AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB). ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:11:21 ]
PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:08:40 ]
Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:05:15 ]
ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3. ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 13:02:10 ]
NVP-BGJ398(BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 12:59:04 ]
Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 12:52:54 ]
GSK 525762A is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4, binds to the tandem bromodomains of BET with Kd of 50.5-61.3 nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5 nM in ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 12:48:50 ]
methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate Name: methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate Synonym: methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate;rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid Methyl Ester;methyl ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Paint & Coatings] [2015-06-03 11:59:28 ]
2,5,6-Triaminopyrimidin-4-ol sulphate Name:2,5,6-Triaminopyrimidin-4-ol sulphate Synonym:2,4,5-Triamino-6-hydroxpyrimidine;2,5,6-triamino-4-pyrimidinohydrogensulfate(ester);2,5,6-triamino-4-pyrimidinomonosulfate;6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE SULPHATE, ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 11:58:52 ]
Name:2-ADAMANTANONE Synonym: ADAMANTANONE TRICYCLO[3.3.1.1(3,7)]DECANE-2-ONE 2-ADAMANTANTANONE TRICYCLO[3.3.1.1~3,7~]DECAN-2-ONE 2-ADAMANTANE KETONE CAS: 700-58-3 EINECS:211-847-2 Assay:99% M.F:C10H14O M.W:150.22 MP:258-260℃ BP: 246.7℃ at 760 mmHg Density:1.105g/cm3 ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 11:58:12 ]
Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Name:Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Molecular Formula:C11H9N3O5 CAS :82551-63-1 Synonyms:p-Nitrobenzyl a-diazoacetoacetate; p-Nitrobenzyl 2-diazoacetoacetate; ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 11:57:43 ]
Ethyl-2-phenyl-2-cyanobutylate Name:Ethyl-2-phenyl-2-cyanobutylate Synonym:(R,S)-Ethylphenylcyano-aceticacidethylester ; ETHYL ETHYLPHENYLCYANOACETATE ; ethylphenylcyano-acetic acid ethyl ester ; (r,s)-2-cyano-2-phenyl-butyric acid ethyl ester ; Ethyl 2-Phenyl-2-cyanobutyl acid ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 11:57:03 ]
