The human Nav1.8 gene encodes the pore-forming subunit of a voltage-gated Na+ channel that is expressed in nociceptive peripheral neurons. Co-expression with the auxiliary beta 3 subunit promotes surface expression. The Nav1.8 channel is a therapeutic target in pain treatment. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 11:03:22 ]
The human GRIN1/GRIN2B genes encode the cationic-selective, n-methyl-d-aspartic acid receptor-channel expressed in the CNS. NMDA receptors are therapeutic targets in treatment of neurological disorders including seizure, pain, and Alzheimer\"s disease. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 11:01:58 ]
The human GRIN1/GRIN2C genes encode an N-methyl-D-aspartate receptor belonging to the ionotropic glutamate receptor family. NMDA receptors expressed in neurons are therapeutic targets in treatment of neurological disorders. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 11:01:14 ]
The human GRIN1/GRIN2D genes encode an N-methyl-D-aspartate receptor belonging to the ionotropic glutamate receptor family. NMDA receptors expressed in neurons are therapeutic targets in treatment of neurological disorders. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 11:00:32 ]
The human P2RX1 gene encodes P2X1, an ionotropic ATP receptor that functions as an ATP- or ADP-activated cation channel, expressed in smooth muscle, platelets, and sensory neurons. A P2RX1 mutation has been linked to a severe bleeding disorder arising from impaired ADP-induced ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:59:48 ]
The human P2RX2 gene encodes P2X2, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in the CNS and dorsal root ganglion neurons. P2X2 channels are therapeutic targets in treatment of pain. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:59:08 ]
The human P2RX2 AND P2RX3 genes encode P2X2/P2X3, aheteromeric ionotropic ATP receptor that functions as an ATP-activated cation channel cation channel expressed in CNS and dorsal root ganglion neurons. P2X2/P2X3 receptors expressed in neurons are therapeutic targets in ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:58:27 ]
The human P2RX3 gene encodes P2X3, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in spinal cord and sensory neurons. P2X3 receptors are therapeutic targets in treatment of neuropathic and inflammatory pain, inflammatory bowel disease, ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:57:46 ]
The human P2RX4 gene encodes P2X4, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in the CNS, alveolar macrophages, vascular endothelium, and airway smooth muscle. P2X4 receptors are therapeutic targets in treatment of neuropathic pain, ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:57:05 ]
The human P2RX7 gene encodes P2X7, an ionotropic ATP receptor that functions as an ATP-activated cation channel expressed in lymphocytes and microglia. P2X7 receptors are therapeutic targets in treatment of osteoporosis, neuropathic and inflammatory pain, and immune diseases. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:56:23 ]
The human TRPA1 gene encodes the pore-forming subunit of TRPA1, a non-selective cation channel expressed in sensory neurons and hair cells. TRPA1 channels are therapeutic targets in treatment of pain. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:54:54 ]
The human TRPC1 gene encodes the pore-forming subunit of TRPC1, a non-selective, cation-permeable channel expressed in the CNS, vascular endothelium and smooth muscle, lymphocytes and epithelia. TRPC1 channels are therapeutic targets in pulmonary hypertension, vascular ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:54:09 ]
The human TRPC6 gene encodes the pore-forming subunit of TRPC6, a non-selective, cation-permeable channel. TRPC6 channels are therapeutic targets in asthma, COPD, cancer, and pulmonary hypertension. ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:53:28 ]
The human TRPM4 gene encodes the pore-forming subunit of TRPM4, a non-selective, cation-permeable channel expressed in lymphocytes, heart, vascular smooth muscle, intestine, and prostate. A gain-of-function mutation in TRPM4 is associated with progressive familial heart block ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:52:47 ]
The human TRPM4 gene encodes the pore-forming subunit of TRPM4 (transient receptor potential channel, subtype M4), a monovalent cation-selective channel. http://www.creative-biogene.com/Human-TRPM4-Stable-Cell-Line-HEK293-196504-12.html ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:51:57 ]
The human TRPM8 gene encodes the pore-forming subunit of TRPM8, a non-selective, cation-permeable channel. TRPM8 channels are therapeutic targets in cancer, overactive bladder, and neuropathic pain. http://www.creative-biogene.com/Human-TRPM8-Stable-Cell-Line-CHO-196505-12.html ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:50:25 ]
The human TRPV4 gene encodes the pore-forming subunit of TRPV4, a moderately selective (PCa/PNa = 6) cation channel. TRPV4 channels are therapeutic targets in pain and asthma. http://www.creative-biogene.com/Human-TRPV4-Stable-Cell-Line-CHO-196509-12.html ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:49:21 ]
The human TRPV6 gene encodes the pore-forming subunit of TRPV6, a Ca2+-selective cation channel expressed in kidney and intestine epithelia. http://www.creative-biogene.com/Human-TRPV6-Stable-Cell-Line-HEK293-196510-12.html ...
Creative Biogene [Health & Medical] [Drugs] [2017-09-18 10:48:37 ]
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N.S.E.Automation Co.,Ltd. [Electrical Equipment & Supplies] [Other Electrical Equipment] [2017-09-18 10:31:10 ]
