Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:52:54 ]
GSK 525762A is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4, binds to the tandem bromodomains of BET with Kd of 50.5-61.3 nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5 nM in
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:48:50 ]
Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Name Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Molecular Formula C11H9N3O5 CAS 82551-63-1 Synonyms p-Nitrobenzyl a-diazoacetoacetate; p-Nitrobenzyl 2-diazoacetoacetate; InChI InChI=1/C11H9N3O5/c1-7(15)10(1
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:57:43 ]
5-hydroxy-4-methoxy-2-nitro-benzaldehyde Name 5-hydroxy-4-methoxy-2-nitro-benzaldehyde CAS 58749-47-6 Package 25kg/drum Standard enterprise Standard MOQ 1kg Price 500 us$/kg
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:51:14 ]
Brexpiprazole (OPC-34712) is a close structural analog of aripiprazole and shares some of its pharmacological properties. Similarly to aripiprazole, brexpiprazole exhibits partial agonism of D2R and an enhanced affinity for specific serotonin receptors (e g., 5-HT1A, 5-HT2A and 5
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:43:47 ]
Ispinesib is a potent, allosteric, reversible, and specific inhibitor of KSP, which changes the binding property of KSP to microtubules and disturbs its movement by inhibiting ADP release without altering the release of the KSP-ADP complex from the microtubule. Ispinesib shows po
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:40:58 ]
N-(2-Chlorobenzyloxycarbonyloxy)succinimide CAS 65853-65-8 MF C12H10ClNO5 MW 283.66 mp 102-105 °C(lit.) storage temp. Store at RT. Chemical Properties Very faintly beige powder Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$150
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:38:32 ]
CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:34:13 ]
MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM).
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:30:36 ]
2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride CAS 908591-25-3 MF C8H14N2S HCl MW 206.74 mp 62-65°C storage temp. Hygroscopic, Refrigerator, Under Inert Atmosphere Chemical Properties White to slightly yellow crystalline powder Usage Intermediate for Ritonavir, a ki
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:25:51 ]
AEE788(NVP-AEE 788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:24:23 ]
SBE13 Hcl is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3. We offer a substantial discount on orders of 5g or more.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:21:21 ]
Isopropyl 2-(3-nitrobenzylidene)acetoacetate CAS 39562-25-9 MF C14H15NO5 MW 277.27 Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$333.3
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:17:23 ]
Felbamate (FBM) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA) .
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:15:50 ]
Pexidartinib(PLX-3397) is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:12:36 ]
SU 6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). By comparing PDGF-stimulated tyrosine phosphorylation events in untreated and SU6656-treated cells, we found that some substrates (for example, c-Cbl, an
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:08:56 ]
BS-181 is a small molecule inhibitor of CDK7 in a cell-free environment, which displays more potential activity than roscovitine with IC 50 of 510 nM. Among the CDKs and other 69 kinases from many different classes, BS-181 shows high inhibitory selectivity for CDK7, inhibits CDK2
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:05:01 ]
PLX647 was tested against a panel of 400 kinases at a concentration of 1 μM, 35-fold above its FMS enzymatic IC50 and 60-fold above its KIT enzymatic IC50. In addition to FMS and KIT, the activities of only nine kinases were inhibited by more than 50%. PLX647 potently inhibits t
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 11:01:11 ]
AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:58:04 ]
Evacetrapib (LY2484595) is a potent and selective inhibitor of CETP with IC50 of 5.5 nM, elevates HDL cholesterol without increases in aldosterone or blood pressure.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 10:53:10 ]
