CaHMB / Sports Nutritional Supplement

HMB chemical profile

HMB (ß-hydroxy-ß-methylbutyrate) is a metabolite of leucine, a branched-chain essential

amino acid consumed from dietary sources. Leucine regulates protein synthesis and helps

maintain nitrogen balance, an indicator of the availability of protein for the body's use.

HMB is the active metabolite of leucine that regulates protein synthesis in muscle cells.

HMB has been shown to inhibit muscle proteolysis and modulate protein turnover.



Chemistry

The chemical formula of HMB is C5H10O3; its molecular weight is 118.13. HMB

is produced commercially by organic chemical synthesis and is supplied as a calcium salt:

CaHMB monohydrate (Ca(C5H9O3)2-H2O).







HMB (ß-hydroxy-ß-methylbutyrate) is a naturally occurring leucine metabolite that rebuilds

lean body mass (LBM) as well as muscle strength. Maintaining LBM, and muscle mass

in particular, is essential to support whole-body protein metabolism, physical strength,

immune function, skin integrity, wound healing, and organ function. LBM loss increases

risk for physical disability, compromises immune function, impairs wound healing, and

increases mortality in the elderly, in people with chronic illness, and in critically ill patients.

HMB addresses underlying factors that alter protein metabolism and helps maintain and

rebuild LBM by stabilizing the muscle membrane and by improving the balance of protein

degradation and protein synthesis within the muscle cell.



The clinical benefits of HMB, alone and as part of a nutrient mixture containing arginine

and glutamine or lysine, have been demonstrated in controlled studies involving elderly

volunteers, patients with LBM loss due to AIDS or cancer, and critically ill patients. Patients

in these studies who received HMB or an HMB–amino acid mixture showed shifts in body

composition with gains in LBM and losses in body fat.

• Elderly women taking HMB plus arginine and lysine had substantial LBM gains

accompanied by significant improvements in muscle strength and functionality

• In elderly volunteers adding HMB to a 5-day weight-resistance exercise program,

substantial increases in LBM were accompanied by significant reductions in body fat

• Patients with LBM loss due to stage IV solid tumors saw significant improvements in

LBM with HMB/ARG/GLN

• In patients with LBM loss due to AIDS, HMB/ARG/GLN provided significant LBM and

body weight gains and significant immune benefits

• HMB improved protein metabolism in critical care patients hospitalized due to trauma

or chronic obstructive pulmonary disease

HMB, at the recommended dose of 3 g daily, has an established profile of safety and

tolerability in the elderly as well as in people with serious illness.

Where to buy CaHMB:

Cima Science is a Chinese and creative company, dedicated to developing, manufacturing and marketing innovative botanical active ingredients, nutritional raw materials for the food, beverage nutraceutical, pharmaceutical, cosmetic and feed industries.

CaHMB and other nutritional raw materials are available here, if any interest, please contact me freely. wang@cimasci.com