Protein-protein interactions (PPIs) are established when protein molecules physically contact with each other through hydrogen or hydrophobic bonds, Van der Waals forces, ionic forces, or even
covalent bonds. This phenomenon underlies a wide range of essential cellular events such as signal transduction, molecular transport and various metabolism pathways. PPIs are also the basic of many
diseases. Therefore, PPIs have been studied extensively in the area of bioscience and medical research.
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