Tetracaine Hydrochloride
CAS: 136-47-0
MF: C15H25ClN2O2
MW: 300.82
Assay: 99%
Description:
Tetracaine hydrochloride is used as a local anaesthetic which acts by reversibly blocking the propagation and conduction of nerve impulses along nerve axons. Tetracaine stabilises the nerve
membrane, preventing the increase in sodium permeability necessary for the production of an action potential.Tetracaine hydrochloride is a calcium channel protein inhibitor and blocks
voltage-sensitive release of Ca2+from sarcoplasmic reticulum. Tetracaine hydrochloride is an inhibitor of Na+ CP type X and Na+ CP type IV
2.Tetracaine hydrochloride is hygroscopic; it has a slightly bitter taste and causes local numbness after being placed on the tongue. Even in the absence of light, it is gradually degraded on
exposure to a humid atmosphere, the decomposition being faster at higher temperatures. Tetracaine hydrochloride melts at about 148 °C or may exist in either of the two polymorphic forms, one of
which melts at 134 °C and the other at 139 °C. Mixtures of the forms melt within the range 134-147°C.
Usage: Tetracaine hydrochloride has been used for studying the pharmacological effects of spinal anesthesia. A crystalline compound related to procaine and used as a local anesthetic.
Application:
Tetracaine is a local anesthetic (numbing medicine). It works by blocking nerve signals in your body.Tetracaine injection is given as an epidural injection into the spinal column to produce
numbness during labor, surgery, or certain medical procedures.Tetracaine may also be used for purposes not listed in this medication guide.
Tetracaine hydrochloride is indicated for the production of spinal anesthesia for procedures requiring two to three hours. Parenteral administration of Tetracaine hydrochloride stabilizes the
neuronal membrane and prevents initiation and transmission of nerve impulses thereby effecting local anesthesia.
The onset of action is rapid, and the duration is prolonged (up to two or three hours or longer of surgical anesthesia).Tetracaine hydrochloride is detoxified by plasma esterases to aminobenzoic
acid and diethylaminoethanol.