The human Nav1.8 gene encodes the pore-forming subunit of a voltage-gated Na+ channel that is expressed in nociceptive peripheral neurons. Co-expression with the auxiliary beta 3 subunit promotes surface expression. The Nav1.8 channel is a therapeutic target in pain treatment. ...
The human GRIN1/GRIN2B genes encode the cationic-selective, n-methyl-d-aspartic acid receptor-channel expressed in the CNS. NMDA receptors are therapeutic targets in treatment of neurological disorders including seizure, pain, and Alzheimer\"s disease. ...