Surface Plasmon Resonance imaging (SPRi) Service

Surface Plasmon Resonance (SPR) is an optical detection process that occurs when a polarized light hits a prism covered by a thin planar metal (typically gold or silver) layer. At certain angles of incidence, a portion of the light energy couples through the gold coating and creates a surface plasmon wave at the sample and gold surface interface. The angle of incident light required to sustain the surface plasmon wave is very sensitive to changes in refractive index at the surface (due to mass change), and it is these changes that are used to monitor the association and dissociation of biomolecules. https://www.creative-peptides.com/services/surface-plasmon-resonance-imaging-spri-service.html

Applications:

Kinetic characterization by Surface Plasmon Resonance and other methods has already been an important step for drug researchers to select and characterize novel therapeutics as well as for basic life scientists to investigate specific biological binding events. When combined with appropriate surface chemistry, microfluidics and software, SPRi is unmatched in its range of applications including:

1. Affinity analysis
2. Kinetic analysis
3. Ligand-fishing
4. Epitope mapping
5. Protein / protein interaction
6. DNA/DNA interactions
7. Protein/carbohydrates
8. Protein / DNA interactions
9. RNA/RNA interactions
10. Antibody (protein) / bacteria interactions
11. Antibody / cell interactions
12. Peptide / protein interactions
13. Polymer / polymer interactions