BIBW 2992
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BIBW 2992 CAS: 439081-18-2 /phoebe@chembj.com
Product Name: BIBW 2992
Synonyms: BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-
butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW 2992);ToMtovok;(S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-
(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide
CAS: 439081-18-2
MF: C24H25ClFN5O3
MW: 485.944
Product Categories: API
density 1.380
Usage: BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2
with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively.
About Afatinib:
Afatinib is a form of biological therapy called a tyrosine kinase inhibitor (TKI). It's a treatment for non small cell cancer of
the lung that has spread outside the lung or to other parts in the body.
How afatinib works
This kind of drug works by blocking particular proteins on cancer cells that let the cancer to grow. Afatinib blocks proteins
called epidermal growth factor receptors (EGFR). Cancers which may have these receptors are known as EGFR positive.
Between 10 and 15 people of the many 100 with non small cell united states (10 to 15%) have EGFR positive cancer. Doctors check
your cancer cells to find out if they have the receptors when you have this treatment.Afatinib may shrink cancer or stop it growing
for a time.
Note:
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Email:phoebe@chembj.com
Skype:+8618827344661
Phone(whatsapp):+8618827344661
- Country: China (Mainland)
- Business Type: Manufacturer
- Market:Global
- Founded Year:2001
- Address:496 Zhongshan Road,Wuhan
- Contact:Caroline Chen
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Product Name: BIBW 2992 Synonyms: BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW ...
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