Nicotiamide Riboside
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Product Name: Nicotiamide Riboside
CAS NO: 1341-23-7
Appearance: white powder
MF: C11H16N2O5
Purity: 99%
Origin: China
Export market: Global
Grade: Pharmaceutical grade
Supply capacity: Mass in stock.
Usage: Anti-aging health products raw materials
Description:
Nicotinamide riboside (NR) is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
In 2016 the FDA granted generally recognized as safe (GRAS) status for NR as a food ingredient in enhanced water products, protein shakes, nutrition bars, gum and chews at no more than 0.027% of NR by weight. The NOAEL and LOAEL in rodents are 300 and 1000 mg/kg/day respectively.
While the molecular weight of nicotinamide riboside is 255.25 g/mol,that of its chloride salt is 290.70 g/mol.As such, 100 mg of nicotinamide riboside chloride provides 88 mg of nicotinamide riboside.
History
NR was first described in 1944 as a growth factor, termed Factor V, for Haemophilus influenza, a bacterium that lives in and depends on blood. Factor V, purified from blood was shown to exist in three forms: NAD+, NMN and NR. NR was the compound that led to the most rapid growth of this bacterium. Notably, H. influenza cannot grow on nicotinic acid, nicotinamide, tryptophan or aspartic acid, which were the previously known precursors of NAD+.
In 2000, yeast Sir2 was shown to be an NAD+-dependent protein lysine deacetylase, which led several groups to probe yeast NAD+ metabolism for genes and enzymes that might regulate lifespan. Biosynthesis of NAD+ in yeast was thought to flow exclusively through NAMN (nicotinic acid mononucleotide).
When NAD+ synthase (glutamine-hydrolysing) was deleted from yeast cells, NR permitted yeast cells to grow. Thus, these Dartmouth College investigators proceeded to clone yeast and human nicotinamide riboside kinases and demonstrate the conversion of NR to NMN by nicotinamide riboside kinases in vitro and in vivo. They also demonstrated that NR is a natural product, a little-noticed vitamin found in cow's milk.
ChromaDex acquired intellectual property on uses and synthesis of NR from Dartmouth College, Cornell University, and Washington University and began distributing NR as Niagen in 2013. In 2015, ChromaDex received New Dietary Ingredient (NDI) status for Niagen from the U.S. Food and Drug Administration (FDA)
- Country: China (Mainland)
- Business Type: Manufacturer,Trading Company
- Market:Americas,Europe,Oceania
- Founded Year:2010
- Address:
- Contact:ava yang
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CAS 23111-00-4 姓名 烟酰胺核苷氯化物 外貌 白色粉末 应用 动物药品 详细说明 请联系我： 邮箱：rachel@sdwenhou.com 柳条：rachel152 WhatsApp :+86-18668960563 包装和交货： 包装：铝箔袋 装液体的瓶子和桶。 ...
Place of Origin:Hebei, China Model Number:23111-00-4 Purity: 99% EINECS No.: / MF: C11H15ClN2O5 Other Names: nicotinamide riboside chloride CAS No.: 23111-00-4 Usage: Animal Pharmaceuticals Grade Standard: Medicine Grade WhatsApp：+8615562518229 ...
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