SGC0946

Place Of Origin
China
Minimum Order
11
Packaging
vial
Delivery
15 Days
Product Name: SGC0946
Synonyms: SGC0946;1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5--bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro-xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro-pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea;1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea;5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-Pyrrolo[2,3-
CAS: 1561178-17-3
MF: C28H40BrN7O4
storage temp. -20°C
Purity : 99%
Appearance : White powders
Package : 1kg/foil bag
Usage : SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.
In vitro :

SGC 0946 is over 100-fold selective for other histone methyltransferases/HMTs. SGC 0946 potently reduces H3K79 dimethylation with IC50 of 2.6 nM in A431 cells, and 8.8 nM in MCF10A cells, which potently and selectively kills cells containing an MLL translocation. SGC 0946 is much more potent than its close analog EPZ004777, and serves as an excellent chemical probe for investigating DOT1L and further development of DOT1L inhibitors for cancer therapy.
Related Histone Methyltransferase Products :

Olaparib (AZD2281, Ku-0059436) CAS: 763113-22-0
MK-1775 CAS: 955365-80-7
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CHIR-99021 (CT99021) HCl CAS: 252917-06-9
SGC 0946 CAS: 1561178-17-3
Entacapone CAS: 130929-57-6
EPZ004777 CAS: 1338466-77-5
UNC1999 CAS: 1431612-23-5
GSK126 CAS: 1346574-57-9
EPZ015666 CAS: 1616391-65-1
MI-2 (Menin-MLL Inhibitor) CAS: 1271738-62-5
MI-3 (Menin-MLL Inhibitor) CAS: 1271738-59-0
EPZ-6438 CAS: 1403254-99-8
3-deazaneplanocin A (DZNeP) HCl CAS: 120964-45-6
GSK343 CAS: 1346704-33-3
BIX 01294 CAS: 935693-62-2
MM-102 CAS: 1417329-24-8
Panobinostat (LBH589) CAS: 404950-80-7
(+)-JQ1 CAS: 1268524-70-4
OG-L002 CAS: 1357302-64-7
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SGC0946
SGC0946

Product Name: SGC0946 Synonyms: ...

Yuancheng Group

SGC0946
SGC0946

Product Name: SGC0946 Synonyms: ...

hubei fangda group