6-Ethylchenodeoxycholic acid

Place Of Origin: China

Minimum Order: 10

Packaging: vial

Delivery: 15 Days

Product Name: Obeticholic Acid

Synonyms: 6-Ethylchenodeoxycholic acid;6alpha-Ethyl-chenodeoxycholic acid;6-Ecdca;6-Ethyl-cdca;C15636;6-Ethylchenodeoxycholic acid(Obeticholic Acid);Obeticholic Acid;(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid

CAS: 459789-99-2

MF: C26H44O4

MW: 420.63

density 1.091

Appearance : White powders

Purity : 99%

Package : 1kg/foil bag

Related categories: pharmaceutical intermediates; pharmaceutical raw materials; Aobei acid; API

Usage : Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM.

In vitro:

In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM.

In vivo:

In rat cholestasis model, Obeticholic Acid promotes bile flow, and protects hepatocytes against acute necrosis caused by LCA. Obeticholic Acid (p.o.) improves proteinuria, ameliorates renal structural changes, and modulates renal inflammation and oxidative stress in WD-fed DBA mice. In thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats, Obeticholic Acid (30 mg/kg p.o.) reactivates the FXR downstream signaling pathway and decreases portal pressure by lowering total IHVR without deleterious systemic hypotension.

Related FXR Products :

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(+)-JQ1 CAS: 1268524-70-4

Osimertinib (AZD9291) CAS: 1421373-66-1

Nintedanib (BIBF 1120) CAS: 656247-17-5

BIBF-1120 CAS: 928326-83-4

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