Clarithromycin

Product Name: Clarithromycin

Synonyms: 6-o-methyl-erythromyci;6-o-methylerythromycina;clathromycin;te-03;TE-031;6-O-METHYLERYTHROMYCIN;6-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYL-OXAN-2-YL)OXY-14-ETHYL-12,13-DIHYDROXY-4-(5-HYDROXY-4-METHOXY-4,6-DIMETHYL-OXAN-2-YL)OXY-7-METHOXY-3,5,7,9,11,13-HEXAMETHYL-1-OXACYCLOTETRADECANE-2,10-DIONE;6-(4-DIMETHYLAMINO-3-HYDROXY-6-METHYLTETRAHYDROPYRAN-2-YL-OXY)-14-ETHYL-12,13-DIHYDROXY-4-(5-HYDROXY)

CAS: 81103-11-9

MF: C38H69NO13

MW: 747.95

Product Categories: Antibiotics;APIs;Antibiotics for Research and Experimental Use;Biochemistry;Macrolides (Antibiotics for Research and Experimental Use);Intermediates & Fine Chemicals;Pharmaceuticals;API's;1694 Pharmaceuticals&Personal Care Products;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;MacrolidesEPA;Neats;Spectrum of Activity;BIAXIN

mp 217-220°C

refractive index -92 ° (C=1, CHCl3)

storage temp. -20°C Freezer

Merck 2339

Stability: Store in Freezer

HS Code 29419000

Chemical Properties Colourless Crystalline Needles

Usage A semi-synthetic macrolide antibiotic. A derivative of erythromycin

Usage antibacterial

Usage Clarithromycin is a semi-synthetic macrolide antibiotic. Clarithromycin is a derivative of Erythromycin (E650000).

Usage Clarithromycin (6-methoxyerythromycin) is a macrolide antibiotic active against a broad range of Gram positive bacteria. Clarithromycin was designed to enhance acid stability and improve oral bioavailability compared with erythromycin which is highly unstable to acidic conditions, undergoing a series of internal ketalisations between the 9-keto moiety and alcohols at C6 and C11. Omura and colleagues found that protection of the labile 6-OH group by methylation provided a simple but elegant solution.