Rimonabant

Quick detail :

Rimonabant

Synonym: ACOMPLIA; RIMONABANT; RIMONABANT(ACOMPLIA, SR141716); 5-(4-Chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide; 1H-Pyrazole-3-carboxamide, 5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-N-1-piperidinyl-; 5-(4-Chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide; A 281; Sr 141716

Melting point: 230 ~ 240 Centigrade

Loss on drying: ≤ 0.5%

pH: (10% solution) 4-7

Heavy metal: ≤ 10ppm

TLC: Only one spot

CAS: 168273-06-1

Assay: ≥ 99.5%

MF: C22H21Cl3N4O

MW: 463.79

Appearance:White powder

Usage:Rimonabant as a new weight loss drug, can also be used to quit smoking. Not only lose weight, but also lower blood pressure, cholesterol and blood sugar, clinical study found that subjects taking one to two months later, the weight can be reduced on average six to eight kilograms.

Description:

Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.