RoMidepsin/Depsipeptide

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Product Name: RoMidepsin/Depsipeptide(FK-228, NSC-63017)
Synonyms: FR 901228;Romidepsin;istodax;RoMidepsin/Depsipeptide(FK-228, NSC-63017);(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone;[S-(E)]-N-(3-Hydroxy-7-Mercapto-1-oxo-4- heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aMinobutanoyl-;Cyclo[(2Z)-2-aMino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-Mercapto-4-heptenoyl-D-valyl-D-cysteinyl] Cyclic (35)-Disulfide;Cyclo[(2Z)-2-aMino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-Mercapto-4-heptenoyl-D-valyl-D-cysteinyl]-d8 Cyclic (35)-Disulfide
CAS: 128517-07-7
MF: C24H36N4O6S2
Product Categories: Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor;API
mp 219-224°C
density 1.174
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
Chemical Properties Pale Yellow Solid
Usage Labelled Romidepsin (R425060). Romidepsin is a histone deacetylase inhibitor that can alter chromatin structure and gene transcription leading to multiple changes in cellular protein production. This may result in cell cycle arrest and tumor growth inhibition. Romidepsin has shown anti-proliferative activity in vitro against multiple mouse and human tumor cell lines and in vivo in human tumor xeno graft models. Romidepsin can be administered with a second agent, such as a cytotoxic agent, a steroidal agent, a proteasome inhibitor, or a kinase inhibitor.

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RoMidepsin/Depsipeptide(FK-228, NSC-63017)
RoMidepsin/Depsipeptide(FK-228, NSC-63017)

Product Name: RoMidepsin/Depsipeptide(FK-228, NSC-63017) Synonyms: FR 901228;Romidepsin;istodax;RoMidepsin/Depsipeptide(FK-228, NSC-63017);(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit ...

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