Combined with the receptors of the anterior pituitary cells, the short-term increase in plasma sex hormone levels. Further use of therapeutic doses resulted in (on average, 12-14 days) complete
blockade of pituitary gonadotropic function, thereby inhibiting the release of LH and FSH. As a result, the synthesis of sex hormones in the ovaries was inhibited and the concentration of estradiol
(E-2) in the plasma decreased to postmenopausal levels.