CAS 74811-65-7 Croscarmellose Sodium

Place Of Origin: china

Minimum Order: 1

Packaging: 1kgs

Delivery: 15 Days

Product Name:Croscarmellose Sodium

Alias:Crosslinked Carboxymethylcellulose Sodium

CAS NO.:74811-65-7

Purity:99%

Appearance:White Powder

Grade:Pharmaceutical Grade

Croscarmellose sodium is an internally cross-linked sodium carboxymethylcellulose for use as a super-disintegrant in pharmaceutical formulations.

The cross-linking reduces water solubility while still allowing the material to swell (like a sponge) and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics, thus improving formulas′ subsequent bioavailability by bringing the active ingredients into better contact with bodily fluids.

Croscarmellose sodium also resolves formulators′ concerns over long-term functional stability, reduced effectiveness at high tablet hardness levels, and similar problems associated with other products developed to enhance drug dissolution. Croscarmellose sodium is a very commonly used pharmaceutical additive.Its purpose in most tablets - including dietary supplements - is to assist the tablet in disintegrating in the gastrointestinal tract promptly. If a tablet disintegrating agent is not included, the tablet could disintegrate too slowly, in the wrong part of the intestine or not at all, thereby reducing the efficacy and bioavailability of the active ingredients.

Croscarmellose is made by first soaking crude cellulose in sodium hydroxide, and then reacting the cellulose with sodium monochloroacetate to form sodium carboxymethylcellulose. Excess sodium monochloroacetate slowly hydrolyzes to glycolic acid and the glycolic acid catalyzes the cross-linkage to form croscarmellose sodium.Chemically, croscarmellose sodium is the sodium salt of a cross-linked, partly O-(carboxymethylated) cellulose.

formula:

1, direct compression formula

The main drug 4-5%, instant sorbitol 30-80%, 5-10% microcrystalline cellulose, croscarmellose sodium 3-7%, magnesium stearate 1%.

Most drugs can be directly tableted using this excipient prescription to produce tablets of good quality.

2, ibuprofen dispersible tablets

The main drug, plus 5% croscarmellose sodium, 5% povidone K30, 15% microcrystalline cellulose, disintegrating agent using the internal addition method, the prescription made of dispersible tablets, tablet quality is excellent

Country: China (Mainland)
Business Type: Manufacturer
Market:Oceania
Founded Year:2016
Address:Lashanhe Road,Huaiyin District,Jinan City
Contact:王女士

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