Megestrol acetate ycgsales02@yccreate.com

Megestrol acetate

English Synonyms:17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione;17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;17-alpha-acetoxy-6-dehydro-6-methylprogesterone;17alpha-Acetoxy-6-dehydro-6-methylprogesterone;17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione17-acetate;5071;6-dehydro-6-methyl-17-alpha-acetoxyprogesterone;6-Dehydro-6-methyl-17alpha-acetoxyprogesterone

CAS:595-33-5

EINECS:209-864-5

MF:C24H32O4

MW:384.51

Purity: 96.0%

Melting point of: 214 ° C

The refractive index of :11 ° (C = 2, CHCl3)

Storage conditions :Refrigerator

Chemical properties : white or slightly yellow crystalline powder (methanol), odorless and tasteless. Melting point 214-216 ℃. Soluble in acetone, slightly soluble in alcohol, ether, insoluble in water.

Use of medroxyprogesterone acetate (MPA) intermediates.

Production methods available 16,17 α-epoxy ring opening of progesterone by hydrogen bromide and nickel-catalyzed reductive debromination produce 17α-hydroxy-progesterone, and then generate 17α-acetoxy progesterone by acetylation and acid hydrolysis, and then the original triethylorthoformate and Vilsmeier etherification reaction to give 3 - ethoxy-6 - formyl-acetoxy-17α-pregna-2, 5 - diene-20 - one, and finally potassium borohydride reduction, acid hydrolysis, dehydration and translocation in the goods.

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