Item | Specification | Result |
Appearance | White powder | Complies |
Related substance (HPLC) | Total impurity ≤0.5% Max single impurity ≤0.1% | 0.2% 0.06% |
Odor | Characteristic | Complies |
Assay | 99% | 99.8% |
Sieve analysis | 100% pass 80 mesh | Complies |
Loss on Drying Residue on Ignition | ≤1.0% ≤1.0% | 0.12% 0.09% |
Heavy Metal | <10ppm | Complies |
As | <0.1ppm | 0.05ppm |
Pb | <0.1ppm | 0.05ppm |
Cd | <0.1ppm | 0.05ppm |
Residual Solvents | <100ppm | Complies |
Residual Pesticide | Negative | Complies |
Microbiology | ||
Total Plate Count | <1000cfu/g | Complies |
Yeast & Mold | <100cfu/g | Complies |
E.Coli | Negative | Complies |
Salmonella | Negative | Complies |
1. AICAR also known as ZMP is an analog of AMP that is capable of stimulating AMP-dependent protein
kinase activity (AMPK). AICAR is being clinically used to treat and protect against cardiac ischemic injury.
2. If left untreated, it may lead to a myocardial infarct. Cardiac Ischemia is caused by insufficient blood flow
and oxygen to the myocardium .
3. The drug was first used in the 1980’s as a method to preserve blood flow to the heart during surgery.
4. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.