NM-2201 is considered an analogue of AM2201, which is itself an artificial cannabinoid with Ki values of 1.0 for the CB1 receptor and 2.6 nM for the peripheral CB2 receptors. NM-2201’s full
physiological effects have not been defined. It is suspected to have many similar effects to the closely related chemicals NNE1 and 5F-PB-22, each of which bind unselectively to both CB1 and CB2
receptors as full agonists with a similar nanomolar affinity.