Treatment of obesity with Xenical (Orlistat) involves making dietary changes as well as regular exercise. Each of these capsules contains 120mg of the active ingredient, and some patients may be instructed by their physician to take it 3 times per day. Generally, one capsule is taken with each meal containing fat. The capsule is usually taken with the meal, however, if it is taken after eating, the patient should take it within 1 hour of finishing the food. The dosage can be skipped if the meal is not eaten, or else if a meal is free of fat.