Apixaban

Minimum Order
1
Packaging
25kg/drum
Delivery
15 Days
Eliquis (apixaban), a direct inhibitor of factor Xa (FXa), was approved by the European Commission on May 18, 2011 for prevention of venous thromboembolic events (VTE) in adult patients who have undergone elective hip or knee replacement surgery. The discovery of apixaban was the culmination of a succession of novel and innovative medicinal chemistry discoveries starting with the identification of nonpeptide leads, rational drug design using computer-aided and X-ray crystallographic information, and the building of drug-like properties through the systematic replacement of basic groups with neutral moieties. Apixaban arose from modifications to razaxaban by constraining a pyrazole amide to form a bicyclic pyrazolo-pyridinone scaffold. Optimization of the P1 group resulted in the identification of the nonbasic methoxy phenyl group, while a P4 piperidinone improved the balance of potency and pharmacokinetics with low Vdss. The synthesis of apixaban begins with the generation of a hydrazone of 4-methoxyaniline which is then used in a 3+2 cycloaddition with a dihydropiperidinone to form a bicyclic pyrazolo-pyridinone scaffold. The distal piperidinone group is installed using an Ullmann coupling reaction followed by aminolysis of an ethyl ester on the pyrazole ring to complete the synthesis of apixaban.
  • Country: China (Mainland)
  • Business Type: Hangzhou Huisheng Biotech Pharmaceutical Co.,Ltd
  • Market:The Middle East,Europea,Russia,and South America and US market
  • Founded Year:2002
  • Address:
  • Contact:Tibi Teng
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Apixaban
Apixaban

慧生药业位于杭州市,经过15年的努力已发展成为领先的制药公司。 我们产品库中的数百种 API 均来自 GMP 来源并具有 DMF/CEP 证书,质量上乘。 ...

HangZhou HuiSheng Biotech Pharmaceutical Co., Ltd

Eliquis Apixaban 5 mg 20 tabs
Eliquis Apixaban 5 mg 20 tabs

Eliquis (apixaban) helps to prevent platelets in your blood from sticking together and forming a blood clot. Eliquis is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called Atrial fibrillation.  Boykaiori18@gmail.com ...

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