Potassium oxalate as an additive for blood collection tubes

At present, many blood tests require the addition of anticoagulants to prevent rapid coagulation of blood and maintain the original physical properties of the blood sample for a certain period of time, in order to facilitate subsequent testing projects. Potassium oxalate is a common anticoagulant reagent that appears as white monoclinic crystals and is easily soluble in water.

The factors that generally affect blood coagulation are as follows:

1. The temperature of the reaction system. When the temperature of the reaction system is lowered below 10 ℃, the activity of thrombin is reduced, which can only delay the time of blood coagulation to a certain extent, but cannot completely prevent blood coagulation.

2. Smooth contact surface. For example, silicification treatment of blood collection tubes is to make the inner wall of the blood collection tubes smooth, reduce platelet aggregation and disintegration, delay the coagulation mechanism triggered by thrombin, and have a certain delaying effect on blood coagulation.

3. Calcium ions (Ca2+). The involvement of calcium ions is required in many stages of blood coagulation, so reducing calcium ions in the blood can delay the time of blood coagulation. The usual approach is to add complex compounds that can bind with calcium to form insoluble but soluble complexes in the blood sample.

Potassium oxalate is the third method that is beneficial for anticoagulation of blood. The main components of potassium oxalate are potassium carbonate and oxalic acid. In junior high school chemistry, it was mentioned that oxalic acid easily reacts with calcium ions to form oxalic acid precipitate, which reduces the coagulation function of calcium ions and achieves anticoagulant effect.

Potassium oxalate, as an anticoagulant, has the advantage of high solubility, but attention should be paid to the dosage when using it, as excessive potassium ions can easily cause dehydration and contraction of blood cells. Due to the precipitation of potassium oxalate with calcium ions in the blood, it has an impact on red blood cells, white blood cells, lymphocytes, and monocytes, making it unsuitable for blood slide examination and platelet classification.

Desheng Company specializes in the production of blood collection tube additives. In addition to potassium oxalate, there are also widely used anticoagulants such as heparin sodium and heparin lithium, as well as serum separation gel, coagulants, etc., with a full range of product types. It has been sold to a wide range of regions both domestically and internationally and has received high praise. If you are interested, please click on the official website to check!