2-Ketoglutaric acid CAS: 328-50-7
Product Quick Detail
- Place Of Origin
- WUHAN
- Packaging
- foil bag or tin
- Delivery
- 7 Days
Specifications
2-Ketoglutaric acid
CAS: 328-50-7
MF: C5H6O5
MW: 146.1
EINECS:206-330-3
Purity:99%
mp 113-115 °C
FEMA 3891
Functions:
Krebs cycle
α-Ketoglutarate is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Anaplerotic reactions can replenish the cycle at this juncture by synthesizing
α-ketoglutarate from transamination of glutamate, or through action of glutamate dehydrogenase on glutamate.
Formation of amino acids
Glutamine is synthesized from glutamate by glutamine synthetase, which utilizes an ATP to form glutamyl phosphate; this intermediate is attacked by ammonia as a nucleophile giving glutamine and
inorganic phosphate.
Nitrogen transporter
Another function is to combine with nitrogen released in the cell, therefore preventing nitrogen overload.
α-Ketoglutarate is one of the most important nitrogen transporters in metabolic pathways. The amino groups of amino acids are attached to it (by transamination) and carried to the liver where the
urea cycle takes place.
α-Ketoglutarate is transaminated, along with glutamine, to form the excitatory neurotransmitter glutamate. Glutamate can then be decarboxylated (requiring vitamin B6) into the inhibitory
neurotransmitter GABA.
It is reported that high ammonia and/or high nitrogen levels may occur with high protein intake, excessive aluminum exposure, Reye's syndrome, cirrhosis, and urea cycle disorder.
It plays a role in detoxification of ammonia in brain
Relationship to molecular oxygen
Acting as a co-substrate, it also plays important function in oxidation reactions involving molecular oxygen.
Dietary supplement
α-Ketoglutaric acids is sold as a dietary supplement and to body builders as AKG or a-KG with the claim that it improves peak athletic performance. This claim is based on studies that show excess
ammonia in the body can combine with alpha-ketoglutarate, reducing problems associated with ammonia toxicity.However, the only studies that show alpha-ketoglutarate can reduce ammonia toxicity have
been performed in hemodialysis patients.
Longevity
A study released on May 14, 2014 links α-ketoglutarate with significantly increased lifespan in nematode worms. Its anion, α-ketoglutarate (α-KG, also called oxo-glutarate) is an important
biological compound. It is the keto acid produced by deamination of glutamate, and is an intermediate in the Krebs cycle.
Usage:
Determination of amino-converting enzyme dehydrogenase substrate reagents measuring liver function, also used as intermediates in organic synthesis. The main purpose as a sports nutrition beverage
ingredients
http://www.steroidsgym.com/
Skype: yczht123456
ycgl08@yccreate.com
- Country: China (Mainland)
- Business Type:
- Market:No.388 Huangshan Road, Tianyuan District, Zhuzhou City, Hunan Province,China
- Founded Year:2013
- Address:No.388 Huangshan Road, Tianyuan District, Zhuzhou City, Hunan Province,China
- Contact:Mr John
Other products from Zhuzhou Yuancheng Hezhong
Relate products of 2-Ketoglutaric acid CAS: 328-50-7
BMK Glycidic Acid CAS 5449-12-7
Name: BMK Glycidic Acid CAS 5449-12-7 Purity: 99% Type: Pharmaceutical Intermediates Appearance: White Powder Function: Pharmaceutical Intermediates: BMK Ethyl Glycidate is commonly used as an intermediate in drug synthesis for the preparation of precursors or active ...
BMK Glycidic Acid CAS 5449-12-7
Name: BMK Glycidic Acid CAS 5449-12-7 Purity: 99% Type: Pharmaceutical Intermediates Appearance: White Powder Function: Pharmaceutical Intermediates: BMK Ethyl Glycidate is commonly used as an intermediate in drug synthesis for the preparation of precursors or active ...
Quickly Ship Laboratory Reagent Hot Sale BMK Glycidic Acid CAS 5449-12-7
Name: BMK Glycidic Acid CAS 5449-12-7 Purity: 99% Type: Pharmaceutical Intermediates Appearance: White Powder Function: Pharmaceutical Intermediates: BMK Ethyl Glycidate is commonly used as an intermediate in drug synthesis for the preparation of precursors or active ...
