4-Hydroxy-2-oxopyrrolidine-N-acetamide CAS:62613-82-5

4-Hydroxy-2-oxopyrrolidine-N-acetamide

Minimum Order Quantity:1kg

Supply Ability:500kg/month

Delivery Time:within 24 hours after payment

Payment Terms:Western Union, MoneyGram, T/T

Package:25kg/drum

Purity:99.0%Min

Appearance:White crystalline powder

Product Description:

CAS:62613-82-5

MF: C6H10N2O3

MW: 158.16

mp:165-168 °C

Oxiracetam is well absorbed from the gastrointestinal tract with a bioavailability of 56-82%. Peak serum levels are reached within one to three hours after a single 800 mg or 2000 mg oral dose, with the maximal serum concentration reaching between 19-31 µg/ml at these doses. Oxiracetam is mainly cleared renally and thus 84% is excreted unchanged in the urine. The half-life of oxiracetam in healthy individuals is about 8 hours, whereas it is 10-68 hours in patients with renal impairment. There is some penetration of the blood-brain barrier with brain concentrations reaching 5.3% of that in the blood (measured one hour after a single 2000 mg intravenous dose). Clearance rates range from 9 to 95 ml/min and steady-state concentrations when 800 mg is given twice daily range from 60 µM to 530 µM. The highest concentrations of oxiracetam is found in the septum pellucidum, followed by the hippocampus, the cerebral cortex and with the lowest concentrations in the striatum after a 200 mg/kg oral dose given to rats.

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