Levodopa CAS: 59-92-7

Levodopa

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CAS: 59-92-7

EINECS: 200-445-2

M.F.: C9H11NO4

M.W. : 197.19

Purity:99%

M.P.: 276-278 °C

L-DOPAis a chemical that is made and used as part of the normal biology of humans, some animals and plants. Some animals and humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines. L-DOPA can be manufactured and in its pure form is sold as a psychoactive drug with the INN levodopa; trade names include Sinemet, Parcopa, Atamet, Stalevo, Madopar, and Prolopa. As a drug it is used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia.

Besides the central nervous system, L-DOPA is also converted into dopamine from within the peripheral nervous system. The resulting hyperdopaminergia causes many of the adverse side effects seen with sole L-DOPA administration. To bypass these effects, it is standard clinical practice to co-administer (with L-DOPA) a peripheral DOPA decarboxylase inhibitor (DDCI) such as carbidopa (medicines combining L-DOPA and carbidopa are branded as Lodosyn, Sinemet, Parcopa, Atamet, Stalevo) or with a benserazide (combination medicines are branded Madopar, Prolopa), to prevent the peripheral synthesis of dopamine from L-DOPA. Co-administration of pyridoxine without a DDCI accelerates the peripheral decarboxylation of L-DOPA to such an extent that it negates the effects of L-DOPA administration, a phenomenon that historically caused great confusion.

Usage:

Parkinsonism effective drug treatment, mainly for Parkinson's disease, etc.

Parkinsonism: mild to moderate illness who is better, or elderly patients with severe efficiency is poor. 2 hepatic coma: can awake patient, symptoms improved. Hepatic coma may be associated with abnormalities of central neurotransmitter dopamine, after use, can be improved and effective central function. 3 Some people think that levodopa may improve brain ammonia tolerance.

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