2-Ketoglutaric acid CAS:328-50-7

2-Ketoglutaric acid

CAS:328-50-7

MF: C5H6O5

MW: 146.1

EINECS:206-330-3

Purity:99%

mp 113-115 °C

FEMA 3891

Functions:

Krebs cycle

α-Ketoglutarate is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Anaplerotic reactions can replenish the cycle at this juncture by synthesizing α-ketoglutarate from transamination of glutamate, or through action of glutamate dehydrogenase on glutamate.

Formation of amino acids

Glutamine is synthesized from glutamate by glutamine synthetase, which utilizes an ATP to form glutamyl phosphate; this intermediate is attacked by ammonia as a nucleophile giving glutamine and inorganic phosphate.

Nitrogen transporter

Another function is to combine with nitrogen released in the cell, therefore preventing nitrogen overload.

α-Ketoglutarate is one of the most important nitrogen transporters in metabolic pathways. The amino groups of amino acids are attached to it (by transamination) and carried to the liver where the urea cycle takes place.

Dietary supplement

α-Ketoglutaric acids is sold as a dietary supplement and to body builders as AKG or a-KG with the claim that it improves peak athletic performance. This claim is based on studies that show excess ammonia in the body can combine with alpha-ketoglutarate, reducing problems associated with ammonia toxicity.However, the only studies that show alpha-ketoglutarate can reduce ammonia toxicity have been performed in hemodialysis patients.

Longevity

A study released on May 14, 2014 links α-ketoglutarate with significantly increased lifespan in nematode worms. Its anion, α-ketoglutarate (α-KG, also called oxo-glutarate) is an important biological compound. It is the keto acid produced by deamination of glutamate, and is an intermediate in the Krebs cycle.

Usage:

Determination of amino-converting enzyme dehydrogenase substrate reagents measuring liver function, also used as intermediates in organic synthesis. The main purpose as a sports nutrition beverage ingredients

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