2-Ketoglutaric acid CAS:328-50-7

2-Ketoglutaric acid

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CAS:328-50-7

MF: C5H6O5

MW: 146.1

EINECS:206-330-3

Purity:99%

mp 113-115 °C

Functions:

Krebs cycle

α-Ketoglutarate is a key intermediate in the Krebs cycle, coming after isocitrate and before succinyl CoA. Anaplerotic reactions can replenish the cycle at this juncture by synthesizing α-ketoglutarate from transamination of glutamate, or through action of glutamate dehydrogenase on glutamate.

Dietary supplement

α-Ketoglutaric acids is sold as a dietary supplement and to body builders as AKG or a-KG with the claim that it improves peak athletic performance. This claim is based on studies that show excess ammonia in the body can combine with alpha-ketoglutarate, reducing problems associated with ammonia toxicity.However, the only studies that show alpha-ketoglutarate can reduce ammonia toxicity have been performed in hemodialysis patients.

Longevity

A study released on May 14, 2014 links α-ketoglutarate with significantly increased lifespan in nematode worms. Its anion, α-ketoglutarate (α-KG, also called oxo-glutarate) is an important biological compound. It is the keto acid produced by deamination of glutamate, and is an intermediate in the Krebs cycle.

Usage:

Determination of amino-converting enzyme dehydrogenase substrate reagents measuring liver function, also used as intermediates in organic synthesis. The main purpose as a sports nutrition beverage ingredients

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