Detailed Product DescriptionQuick Details:
Gamma-Butyrolactone
Alias: Gamma Butyrolactone, 1, 4- Butyrolactone, γ -Butyroladone, GBL, BLO
Purity : 99.0%
CAS Registry Number: 96-48-0
Einecs No: 202-509-5
MF: C4H6O2
MW: 86.09
Melting Point:-44°C
Boiling Point:206°C
Flash Point:99.2°C
Ignition temperature:455°C
Refractive Index:nd20 :1.434~1.440
Density 1.12 g/mL at 25 ° C(lit. )
Storage temp. 2-8° C
Chemical Properties: Colourless oily liquid
Appearance:Colorless clear oily liquid with acetone-like odor
Product Categories: Pharmaceutical Intermediates;Heterocycles;Miscellaneous Reagents
Manufacturer : Wuhan Hezhong Bio-Chemical Manufature Co.,Ltd
Lead time :within 24 hours upon receipt of payment
Packing: Galvanied iron barrel,net weight:200kg±0.05
Uses:
(1) GBL can be used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone , polyvinyl pyrrolidone, and α-Acetyl-γ-butyrolactone, etc.
(2)GBL can be used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the intermediate of vitamin and rolicyprine;
(3) GBL is the intermediate of plant growth stimulator and insecticide
(4)GBL is a good antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent; Moreover, it can also be used in battery, capacitor and development of color film.
Product Description:
Gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as well as
being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as
a recreational intoxicant with effects similar to alcohol.
GBL has been found in extracts from samples of unadulterated wines.[3] This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products. The
concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. GBL can be found in cheese flavourings but typically results
in a content of 0.0002% GBL in the final foodstuff.
GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic
conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can
become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.
GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB.
The hypnotic effect of GHB is enhanced by combination with alcohol. A 2003 rat study showed that GBL in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure
was longer than both of the individual components combined
GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood.[7][8] Animals which lack these enzymes exhibit no effect from GBL.[7] GBL is more lipophilic (fat soluble)
than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent and faster-acting than GHB, but has a shorter duration;
whereas the related compound 1,4-butanediol (1,4-B) tends to be slightly less potent, slower to take effect but longer-acting than GHB.
Application:
1)it is Used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone, polyvinyl pyrrolidone, and α -Acetyl-γ -butyrolactone;
2) it is used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the intermediate of vitamin and rolicyprine;
3) As antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent;
4) it is Used in battery, capacitor and development of color film.
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