Canrenone

Canrenone
Alias: 17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone
CAS NO:976-71-6
Product Categories:Spironolacrone;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;ASMANEX
Appearance:Pale yellow to pale Green Solid
Molecular weight:340.46
Molecular formula:C22H28O3
EINECS:213-554-5
Packing:Foil bag
Usage:Aldosterone antagonist. Diuretic
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Product Details:
Place of Origin: China
Brand Name: Yuancheng
Certification: GMP,SGS,ISO,KOSHER,
Model Number: 976-71-6
Payment & Shipping Terms:
Minimum Order Quantity: 10g
Payment Terms: Western Union, MoneyGram, T/T

Description
The properties of the aldosterone antagonists spironolactone and potassium canrenoate in tablet formulations were examined in two studies in healthy subjects, the first study comparing levels of their common major metabolite, canrenone, in plasma and the second study comparing the pharmacological activity of the two drugs in reversing the renal effects of the synthetic mineralocorticoid fludrocortisone.
At equal dosage by weight potassium canrenoate yielded peak levels and areas under the curve for canrenone in plasma which were significantly lower than those for spironolactone, and the peak level of canrenone was reached significantly later. Comparison with published work suggests that the experimental formulation of potassium canrenoate had low bioavailability.
Spironolactone produced statistically valid log dose-response curves against fludrocortisone as regards sodium excretion, potassium retention and increased urine sodium to potassium ratio. There was no significant log dose-reponse after potassium canrenoate, and a statistically valid estimate of relative potency could not be obtained.
The results of the two studies seem inconsistent with the view that canrenone alone is responsible for the pharmacological activity of both drugs, and suggest that a significant part of the activity of spironolactone may be attributable to metabolites other than canrenone.


Applications:
Canrenone (Contaren, Luvion) is an aldosterone antagonist with additional antiandrogen properties which is used as a diuretic in Europe.
It is a major active metabolite of spironolactone, and is believed to be partially responsible for its effects.

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