Product Details
Basic Info.
Classification:Amino Acid
CAS:60-18-4
Einecs:200-460-4
Rtecs:Yp2275600
Brn:392441
Pubchem:24900164
Mdl:Mfcd00002606
Appearance:White Crystals or Crystalline Powder
Product Description
Indication
Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims
have been refuted by some studies.
Pharmacodynamics
Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. Tyrosine is critical for the production of the body's proteins, enzymes and muscle tissue. Tyrosine is a precursor
to the neurotransmitters norepinephrine and dopamine. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. Tyrosine aids in the production of
melanin and plays a critical role in the production of thyroxin (thyroid hormones). Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental
tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue.
Mechanism of action
Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes
into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be
accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be
associated with antidepressant effects.
Absorption
L-tyrosine is absorbed from the small intestine by a sodium-dependent active transport process.
Metabolism
In the liver, L-tyrosine is involved in a number of biochemical reactions, including protein synthesis and oxidative catabolic reactions. L-tyrosine that is not metabolized in the liver is
distributed via the systemic circulation to the various tissues of the body.
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