Crystals 5-APB CAS 286834-81-9

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5-APB (5-(2-aminopropyl)benzofuran, 1-benzofuran-5-ylpropan-2-amine, benzofury) is a triple monoamine reuptake inhibitor with K_i values of 180, 265 and 811 nM for NET, DAT and SERT respectively as well as being a potent agonist for the 5-HT_2A and 5-HT_2B receptors (K_i of 14nM at 5-HT_2B).This agonism for 5-HT_2B makes it likely that 5-APB would be cardiotoxic with long term use, as seen in other 5-HT_2B agonists such as fenfluramine and MDMA. The subjective effects and structure-activity relationship suggest that 5-APB is also a monoamine releasing agent. Preliminary evidence suggests 5-APB is an inhibitor of the CYP2D6 enzyme.

5-APB is commonly found as the succinate and hydrochloride salt. The hydrochloride salt is 10% more potent by mass and doses should be adjusted accordingly.

It has been sold as a designer drug since 2010. Anecdotal reports from users suggest it hasstimulant and empathogenic effects, but less psychedelic action than related compounds such as 6-APB and 5-APDB.

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