AP26113 (Cas No.1197958-12-5)
Product Quick Detail
- Cas No.
- 1197958-12-5
- Formula
- C26H34ClN6O2P
- M.Wt
- 529.01
- Purity
- 98%
- Solubility
- DMSO 45 mg/mL; Water <1 mg/mL; Ethanol 106 mg/mL
- Synonyms
- AP-26113; AP 26113
- Packaging
- Fluorinated Bottles
- Delivery
- 7 Days
Specifications
AP-26113 exhibited approx 100-fold selectivity for ALK-positive lines compared with a approx 10-fold selectivity for PF-1066. At the highest doses tested, strong regressions were
achieved with AP-26113, but not PF-1066 .AP-26113 inhibited the tumor growth at 25 mg/kg in ALCL and at 10 mg/kg in NSCLC models [1]. AP26113 inhibits cell growth with IC50 of 11 nM and 16 nM in
Ba/F3 line (native EML4-ALK) and Ba/F3 line (EML4-ALK G1269S mutants). AP26113 inhibits ALK phosphorylationh with IC50 of 74 nM and 335 nM in Ba/F3 line (native EML4-ALK) and Ba/F3 line (EML4-ALK
E1210K mutants). AP26113 (10 mg/kg-75 mg/kg) is efficacious in PF-02341066-resistant EML4-ALK mutant mouse xenograft models.
- Country: China (Mainland)
- Market: European Union,Americas
- Founded Year: 2009
- Address: 武汉东湖高新区长城科技园光谷精工D栋402室
- Contact: Rosie Liu
