AP26113 (Cas No.1197958-12-5)

Cas No.
1197958-12-5
M.Wt
529.01
Solubility
DMSO 45 mg/mL; Water <1 mg/mL; Ethanol 106 mg/mL
Formula
C26H34ClN6O2P
Purity
98%
Synonyms
AP-26113; AP 26113
Packaging
Fluorinated Bottles
Delivery
7 Days
AP-26113 exhibited approx 100-fold selectivity for ALK-positive lines compared with a approx 10-fold selectivity for PF-1066. At the highest doses tested, strong regressions were achieved with AP-26113, but not PF-1066 .AP-26113 inhibited the tumor growth at 25 mg/kg in ALCL and at 10 mg/kg in NSCLC models [1]. AP26113 inhibits cell growth with IC50 of 11 nM and 16 nM in Ba/F3 line (native EML4-ALK) and Ba/F3 line (EML4-ALK G1269S mutants). AP26113 inhibits ALK phosphorylationh with IC50 of 74 nM and 335 nM in Ba/F3 line (native EML4-ALK) and Ba/F3 line (EML4-ALK E1210K mutants). AP26113 (10 mg/kg-75 mg/kg) is efficacious in PF-02341066-resistant EML4-ALK mutant mouse xenograft models.
  • Country: China (Mainland)
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  • Market:European Union,Americas
  • Founded Year:2009
  • Address:武汉东湖高新区长城科技园光谷精工D栋402室
  • Contact:Rosie Liu
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