PLX647 (Cas No. 873786-09-5)

Cas No.
873786-09-5
M.Wt
382.38
Solubility
DMSO 20 mg/ml
Formula
C21H17F3N4
Purity
98%
Synonyms
PLX-647
Packaging
Fluorinated Bottles
Delivery
7 Days
PLX647 was tested against a panel of 400 kinases at a concentration of 1 μM, 35-fold above its FMS enzymatic IC50 and 60-fold above its KIT enzymatic IC50. In addition to FMS and KIT, the activities of only nine kinases were inhibited by more than 50%. PLX647 potently inhibits the growth of FLT3–ITD-expressing MV4-11 cells (IC50 = 0.11 μM) but not OCI-AML5 (IC50 = 1.6 μM), which express wild-type FLT3.
  • Country: China (Mainland)
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  • Founded Year:2009
  • Address:武汉东湖高新区长城科技园光谷精工D栋402室
  • Contact:Rosie Liu
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