TB-500 Thymosin Beta-4 Acetate

TB-500 Thymosin Beta-4 Acetate Safe Package Fast Delivery TB-500

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TB500

Sequence:Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH

TB500 CAS No.77591-33-4

TB500 One Letter Sequence:Ac-SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQAGES

TB500 Specification:2mg/5mg/10mg

TB500 Appearance:White powder

TB500 Form & Formulations:Sterile Filtered white lyophilized (Freeze-Dried)

Purity: 99%

Specification: 2mg/vial 1g/bags

Appearance: White Lyophilized Powder

Place of Origin: China

Standard: USP

Certification: SGS

Method of Analysis: HPLC

Product Usage: ­­THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

Thymosins are small proteins present in many animal tissues. They are named thymosins because they were originally isolated from the thymus, but most are now known to be present in many other tissues. Thymosins have diverse biological activities, and two in particular, thymosins α1 and β4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In relation to diseases, thymosins have been categorized as biological response modifiers.

TB-500 (Thymosin Beta 4 )

is a synthetic version of the naturally occurring peptide present in virtually all-human and animal cells, Thymosin Beta 4 (TŸ4). It is a first-in-class drug candidate that promotes the following*:

WHAT THIS DOES:

1.Increases Red Blood Cells

2.Stops bleeding

3.Increase Endurance

4.Reduces Tie Up

5.Helps breathing

6.Reduces stomach acid which eliminates ulcers

7.Increases lean muscle mass

8.Helps repair tendons and ligaments

* Endothelial (blood vessels) cell differentiation (increases red blood cells)

* Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues

* Keratinocyte migration

* Collagen deposition; and

* Decreases inflammation.

One of TŸ4 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins which therefore plays a major role in the genetic makeup of the cell.

This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. TŸ4 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.

TŸ4 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.

An additional key factor of TŸ4 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.

Research confirms that TŸ4 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. TŸ4 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.

HOW TO USE: Give one 2ml vial subcutaneous each week for six consecutive weeks. There after use one 2ml vial per month. It's best to give injection 6 days before intense work.

We recommend giving the shot the day after intense work then giving the shot every seven day there after. You must make sure to hydrate very well when using this product. Give normal vitamins and minerals to support normal racing function. Hydration is key when using this product.

BPC 157 (Body Protection Compound-157) is a pentadecapeptide made up of 15 amino acids. The amino acids sequence in BPC 157 is similar to a portion of the human BPC amino acid sequence. Human BPC is found in the gastric juice. Experiments have shown that BPC 157 enhances the healing of wounds, including tendons wounds such as transected Achilles tendons of rats. The aim of this study was to investigate the probable mechanism that BPC 157 utilizes to accelerate the healing process in an injured tendon. The study used two group of tendon explants of which one group was cultured in a BPC 157-containing medium while the other group was cultured in a medium lacking BPC 157. These cultures were thereafter examined for tendon fibroblasts outgrowths. Such outgrowths indicated tendon regeneration.The results revealed that the explants’ outgrowth was significantly accelerated in the culture containing BPC 157 as compared to the culture lacking BPC 157. Also, a MTT assay did show that BPC 157 does not directly affect cellular proliferation in a culture of rat-derived Achilles tendon. However, results also showed that BPC 157 significantly increased the survival of cells under oxidative stress. Furthermore, the Transwell filter migration assay showed that BPC 157 significantly increased in-vitro fibroblast migration in a dose-dependent fashion. Moreover, BPC 157 accelerated the dispersal of the fibroblasts in culture dishes in a dose-dependent manner.

Additionally, FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.

Thus, it can be concluded that BPC 157 enhances the ex-vivo growth and in-vitro cellular migration of fibroblasts derived from rat tendon explants. Moreover, BPC 157 also increases the probability of a cell surviving under oxidative stress. These actions of BPC 157 are probably mediated by the activation (through phosphorylation) of the proteinic FAK-paxillin pathway.

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