PEG MGF, 2mg/vial
Active Substance: It is PEGylated MGF
Synonyms :peg MGF,Mechano growth factor,IGF-1 EC
Molecular :Formula C121H200N42O39
Molecular Weight :2948.15+(1800-2000)
Sequence :PEG-Suc-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-D-Arg-D-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2
Appearance :White Powder
Identity (ESI-MS) :2948.15±3.0(MGF)
Source :Chemical Synthesis
Storage :Lyophilized Peg MGF is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting Peg MGF should be
refrigerated at temperatures not to exceed 36 F. .
Application: PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is
that this will allow the MGF to be carried through the blood stream without being broken down
PEG-MGF, or PEGylated Mechano Growth Factor is a new and innovative form of MGF that outperforms natural MGF many times over. MGF is a splice variant of the IGF gene which increases stem cell count
in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic
MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes.
PEGylated protein (PEG-MGF) is the one that has Polyethylene Glycol added to it. The role of the Polyethylene Glycol molecule is to preserve the integrity of the Mechano Growth Factor. Unlike the
naturally produced Mechano Growth Factor, the injected MGF needs to enter the circulatory system. That is where the problem for the MGF arises. MGF is not stable in such environment and in order to
be able to reach its final destination and fulfill its role it needs to be PEGylated (and turned into PEG-MGF). Polyethylene Glycol serves as a kind of a shell protecting the MGF from reacting to
its surroundings before it reaches its final destination. It makes the PEG-MGF much more stable and long-lasting than Machano Growth Factor could be on its own.