Sodium levothyroxine CAS:25416-65-3

Sodium levothyroxine CAS:25416-65-3

MF: C15H10I4NNaO4

MW: 798.85

EINECS: 200-221-4

Product Categories: Hormone Drugs

Mol File: 25416-65-3.mol

Chemical Properties

mp : 207 °C

alpha : 16 o (c=2,1M HCl/alcohol 1/4)

storage temp. : Store at 0-5°C

Water Solubility : 0.15 g/L (25 oC)

CAS DataBase Reference: 25416-65-3(CAS DataBase Reference)

Levothyroxine is a synthetic (man-made) version of the principle thyroid hormone, thyroxine (T4) that is made and released by the thyroid gland. Thyroid hormone increases the metabolic rate of cells of all tissues in the body. In the fetus and newborn, thyroid hormone is important for the growth and development of all tissues including bones and the brain. In adults, thyroid hormone helps to maintain brain function, utilization of food, and body temperature, among other effects.

Applications :

Levothyroxine is typically used to treat hypothyroidism,and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy.It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing.Levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion.

Dosage:

Available as levothyroxine sodium; dosage is expressed in terms of the salt.

Adjust dosage carefully according to clinical and laboratory response to treatment. Avoid undertreatment or overtreatment. (See Therapy Monitoring under Cautions.)

Initiate dosage at a lower level in geriatric patients, in patients with functional or ECG evidence of cardiovascular disease, and in patients with severe, long-standing hypothyroidism.