Dextromethorphan Hydrobromide

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Procuct Mame :Dextromethorphan Hydrobromide

Alias: Dextromethorphan Hbr, Dextromethorphan Hydrobromicum, Dextromethorphan Hydrobromide, Romilar

Dextromethorphan Hydrobromide

CAS Number: 125-69-9

Formula: C18H26BrNO

Molecular Weight: 352.3091

Synonyms: Dextromethorphan Hydrobromide; Dextromethorphan HBr

EINECS: 204-750-1

Boiling Point: 427.5 C at 760 mmHg

Flash Point: 212.3 C

Assay: 99% min

Appearance: White crystalline powder

Usage: The central Antitussives mainly inhibit the extension of the brain's cough center and play a role, used for treatment of little phlegm cough caused by colds, acute and chronic bronchitis, sore throat, bronchial asthma, tuberculosis and other upper respiratory tract infections.

Description:

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.

Applications:

It can Inhibit medullary cough center to produce antitussive effect. Normal therapeutic dose does not inhibit breathing, long-term use without addiction and tolerance.

Dextromethorphan (DXM or DM) is an antitussive (cough suppressant) drug.

Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, dextromethorphan occurs as a white powder.

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