Ceramide PC-104 (Inci Name: Hydroxypropyl Bispalmitamide Mea)

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For Mor info. :

Moisture retainning effect , Emollient effect,,Barrier function, Anti-aging, Cure for rough skin
, Stratum Corneum turn-over function, Activation of skin function, Hair care, Hair growth,  Promotion Hair loss prevention, Amino acid, protein stabilization, Improve hair and nail function, Anti-dandruff

Applications :

* Before ceramide application, Acetone was treated for 5 min. under occlusion and rinsed with
warm water
* % reduction : (Tb - Ta) / Tb x 100 Tb : initial TEWL(base line), Ta : after application TEWL

Vehicle                                                7.1              36.2

N-Stearoylphytoshingosine                   31.5             49.1

Compound IV                                      27.3             45.2

Compound III                                       38.2             55.2

Compound II                                        37.5             48.3

Ceramide PC-104                                40.2              57.3  

                                                          4hr               8hr

Sample                                              Reduction ratio(%)*

Restoration effect on Acetone-induced skin damage

Histopathological Findings :
(Effect on 2.5% SDS damaged skin of Hairless Guinea Pig)

* Before ceramide application, 2.5% SDS was treated for 30 min. under occlusion and rinsed
with warm water
* % reduction : (Tb - Ta) / Tb x 100 Tb : initial TEWL(base line), Ta : after application TEWL

Control                                       15.7               19.9

Base lotion                                 17.5               25.3

N-Oleoylphytoshingosine             19.0               39.2

Compound IV                              17.7              32.9

Compound III                              19.2               37.9 

Compound II                               18.9              38.2

Ceramide PC-104                       19.5               39.1

                                                 7hr                24hr

Sample                                      Reduction ratio(%)*

Restoration effect on SDS-induced skin damage :

- Consist of 6 heterogeneous classes.
- Contain sphingosine or phytosphingosine base in amide linkage with non-hydroxy,

The most important lipids of the barrier function in Stratum corneum.