OfloxacinPromed Tablets (200mg)

Therapeutic Category :Synthetic broad-spectrum antimicrobial agentComposition :Each film-coated tablet contains1. Ofloxacin USP 200 mgPharmacology :Ofloxacin is a synthetic broad-spectrum antimicrobial agent for oral administration. Ofloxacin is an anti-infective drug used for the treatment of lower respiratory infections, skin infection, and urinary tract infections including prostatitis, gonorrhea, cervicitis and urethritis. Ofloxacin has broad activity against bacterial infections and is used in combination with other drugs to treat tuberculosis.Indications :Ofloxacin tablets are indicated for the treatment of adults with mild to moderate infections (unless other-wise indicated) caused by susceptible strains of the designated microorganisms in the infections listed below.Acute bacterial exacerbations of chronic bronchitisCommunity-acquired PneumoniaUncomplicated skin and skin structure infectionsNongonococcal urethritis and cervicitisMixed infections of the urethra and cervixAcute pelvic inflammatory diseasePulmonary and non-pulmonary tuberculosisUncomplicated cystitisComplicated urinary tract infectionsProstatitisDosage :The usual dose of Ofloxacin tablets is 200 mg to 400 mg orally every 12 h as described in the following dosing chart. These recommendations apply to patients with normal renal function (i.e., creatinine clearance 50 mL/min).InfectionUnit DoseFrequencyDurationDaily DoseAcute exacerbation of Chronic Bronchitis400 mgq12h10 days800 mgComm. Acquired Pneumonia400 mgq12h10 days800 mgUncomplicated Skin and Skin Structure Infections400 mgq12h10 days800 mgAcute, Uncomplicated Urethral and Cervical Gonorrhea400 mgsingle dose1 day400 mgNongonococcal Cervicitis/Urethritis due to C. trachomatis300 mgq12h7 days600 mgMixed Infection of the urethra and cervix due to C. trachomatis and N. gonorrhoeae300 mgq12h7 days600 mgAcute Pelvic Inflammatory Disease400 mgq12h10-14 days800 mgUncomplicated Cystitis due to E. coli or K. pneumoniae200 mgq12h3 days400 mgUncomplicated Cystitis due to other approved pathogens200 mgq12h7 days400 mgComplicated UTI's200 mgq12h10 days400 mgProstatitis due to E. coli300 mgq12h6 weeks600 mgPulmonary and extra pulmonary Tuberculosis400 mgq12h8-12 weeks 800 mg DUE TO THE DESIGNATED PATHOGENS Depending upon severity of case and concomitant drugs used.Antacids containing calcium, magnesium, or aluminum; Sucralfate; divalent or trivalent cations such as iron; or multivitamins containing zinc; should not be taken within the two-hour period before or within the two-hour period after taking Ofloxacin.Patients with Impaired Renal Function :Dosage should be adjusted for patients with a creatinine clearance ?50 mL/min. After a normal initial dose, dosage should be adjusted as follows:Creatinine ClearanceMaintenance DoseFrequency2050 mL/minthe usual recommended unit doseq24h20 mL/min1/2 the usual recommended unit doseq24hWhen only the serum creatinine is known, the following formula may be used to estimate creatinine clearance.Men: Creatinine clearance (mL/min) = {Weight (kg)