Acetyl Coenzyme A sodium salt

In the transfer reaction by Acetyl CoA of the C2 acetyl fragment, either the carboxyl group or the methyl group may react (electrophilic vs. nucleophilic reaction, respectively).

 The biosynthetic pathways for Acetyl CoA have been illustrated.

The acetic acid moiety which is bound by a high-energy bond (free energy 34.3 kJ/mol) to the -SH group of Coenzyme A is a precursor to fatty acids, steroids and other naturally occurring compounds, such as terpenes and acetogenins present in plants.

Coenzymes comprise a class of molecules, generally derived from vitamins, which function catalytically in enzyme systems.

methods for the determination of Acetyl CoA and other CoA derivatives have been described in the literature.

The product is purified by ion exchange chromatography.  Several methods of preparation and

A8071 is prepared enzymatically by reacting Coenzyme A with Acetyl Phosphate and Phosphotransacetylase. 

EM(232nm) = 8,700 (water)

EM(259nm) = 15,400 (0.1 M PO4 Buffer, pH 7)

EM(260nm) = 16,400 (water)

Molecular Weight: 809.6 (for free acid)

Molecular Formula: C23H38N7O17P3S (for free acid)

Appearance: White powder

 Product Description

An essential cofactor in enzymatic acetyl transfer reactions.