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MPT can assist you in custom-tailoring advanced separation technologies to meet your specific process requirements.
In this scenario, the chiral product was produced on a campaign basis. By outsourcing their biocatalyst recovery processes, the client kept capital and technical resources focused on implementing high purity purification technologies for the final chiral product.
The first step in the process was to separate the soluble biocatalyst and the chiral compound from the very small (0.2 to 0.5 micron)particulate matter present in the bioreactor mixture. MPT accomplished this step via an inorganic HyperFluxTM microfiltration (MF) system. The permeate of the MF system containing the soluble enzyme and chiral product was collected in a storage vessel (V2). The soluble enzyme was then separated from the chiral compound by passing the solution through a HyperFluxTM ultrafiltration system (UF). The concentrated reject containing the enzyme biocatalyst of the UF membrane filter was recycled to the bioreactor, and the permeate containing the chiral compound was sent to a conventional separation process for further purification.
Mobile Process Technology provided the client with a comprehensive turnkey separation solution-from process development and pilot testing to onsite biocatalyst recovery services. Working closely with the client's technical staff, MPT developed an advanced membrane separation process to recover and reuse the soluble biocatalyst (MW=3500) from the chiral product (MW=350), utilizing MPT's proprietary HyperFluxTM membrane system.
A client of Mobile Process Technology (MPT) required the separation of an expensive soluble biocatalyst (enzyme) from a chiral compound (API) produced in a biochemical reaction process. Due to the enzyme's temperature sensitivity, conventional thermal separation methods were prohibitive.
Many chemical manufacturing processes require biocatalysts to produce Active Pharmaceutical Intermediates (API). Due to the heat-sensitive nature of many API compounds, innovative separation technologies must be utilized in order to avoid the high operating temperatures encountered in conventional distillation processes.
Hyper Flux Biocatalyst Recovery Technology
Hyper Flux Biocatalyst Recovery Technology Background |
Epoxidation---------------------------------------------------Mo,W Esterification----------------------------------------------Sb,Ge,Ti Oxidation-----------------------------------------Pt,Pd,Rh,Co,Mn Carbonylation---------------------------------------Pd,Ru,Rh,Co ...
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