"Such high levels of a urokinase inhibitor are likely to have a physiological effect and could reduce incidence of cancer in humans or the size of cancers already formed"
"Amiloride is administered in a maximum dose of 20 mg per day, whereas a single cup of tea contains 150 mg (of) EGCG, and some tea lovers consume up to 10 cups a day," they wrote.
Jankun's group compared the dose of cathechins in green tea to a drug, amiloride, that acts in a similar way but is usually used to treat high blood pressure and congestive heart failure.
Black tea - the type drunk most often in the West - does not work in this way because the brewing process destroys the effects of the cathechins.
"Inhibition of urokinase can decrease tumour size or even cause complete remission of cancers in mice," Jankun's group wrote.
Jankun's group said they had found epigallocathechin-3 gallate (EGCG) acted against urokinase, which is often found in large amounts in human cancers. EGCG attaches to it and prevents it from invading cells and forming tumors.
Researchers knew tea and especially green tea contained chemicals that could protect against cancer but have been unable to identify the precise mechanism.
"One of the major ingredients of green tea inhibits urokinase, an enzyme crucial for cancer growth," Jerzy Jankun of the Medical College of Ohio in Toledo and colleagues wrote in a letter to the science journal Nature.
CHEMICAL IN GREEN TEA STOPS TUMORS : STUDY SAYS
LONDON (Reuter) - Green tea could help prevent cancer through the action of a chemical known as a cathechin, researchers in the United States reported Wednesday. They said it was non-toxic in doses
found in tea-but a single cup of green tea contained huge amounts of the chemical.
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