4,4-Diethoxy-N,N-dimethyl-1-butanamine CAS 1116-77-4 MF C10H23NO2 MW 189.3 bp 194-195C density 0.844 g/mL at 25 °C(lit.) refractive index n20/D 1.421(lit.) Fp 158 °F Chemical Properties Light yellow liquid Purity 96% Usage API Package 1KG foil bag; 25Kg drum Price us$250
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 14:30:50 ]
4-fluoro-alpha-(2-methyl-1-oxopropyl)-gama-oxo-n,beta-diphenylbenzene butaneamide Name 4-fluoro-alpha-(2-methyl-1-oxopropyl)-gama-oxo-n,beta-diphenylbenzene butaneamide EINECS 425-850-3 Molecular Formula C26H24FNO3 CAS 125971-96-2;125971-58-6 Synonyms 2-[2-(4-Fluorophenyl)-2-oxo
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 14:29:11 ]
3-(N-Methylpentylamino)propionic acid hydrochloride CAS 625120-81-2 MF C9H20ClNO2 MW 209.71 mp 101-103°C storage temp. Refrigerator Chemical Properties White Solid Usage An intermediate in the preparation of biphosphonate drugs used in the prevention and treatment of osteoporosi
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 14:20:54 ]
Name 3-METHYL-4-NITROBENZOIC ACID Synonym 4-NITRO-M-TOLUIC ACID 3-METHY-4-NITROBENZOATIC ACID 4-NITRO-3-METHYL BENZOIC ACID M-METHYL-P-NITROBENZOIC ACID 3-METHYL-4-NITROBENZOATE RARECHEM AL BO 0346 3-METHYL-4-NITRO-BENZOICACI BENZOIC ACID, 3-METHYL-4-NITRO- M-TOLUIC ACID, 4-NITRO
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 14:17:27 ]
3-Bromo-4-hydroxy-5-nitropyridine Name 3-Bromo-4-hydroxy-5-nitropyridine Synonym 3-Bromo-4-hydroxy-5-nitropyridine;5-BroM-3-nitro-4-pyridinol;3-broMo-5-nitro-4-pyridone;4-Hydroxy-3-nitro-5-broMopyridine;4-Pyridinol, 3-broMo-5-nitro- CAS 31872-65-8 MF C5H3BrN2O3 MW Assay 98% Packa
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 14:13:37 ]
JSH-23 exhibited inhibitory effect with an IC(50) value of 7.1 microM on nuclear factor (NF)-kappaB transcriptional activity in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7, and interfered LPS-induced nuclear translocation of NF-kappaB without affecting IkappaB degra
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:46:33 ]
DMH-1 is a potent and selective BMP inhibitor with IC50s of 27/107.9/<5 nM for ALK1/2/3 respectively; inactive on ALK5, BMPR2, AMPK and VEGFR2.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:42:54 ]
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:40:24 ]
6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:38:22 ]
LDN193189(DM 3189) is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:34:40 ]
AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Prolonged exposure with AZ20 increases H2AX pan-nuclear staining, indicative of replication stress.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:30:46 ]
CZC24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay); exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:27:07 ]
RKI-1447 inhibits potently ROCK1 and ROCK2 in a dose-dependent manner with IC50 values of 14.5 nM and 6.2 nM, respectively. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but had no effect on the phosphorylation levels of the AK
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:23:13 ]
SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:18:17 ]
UNC2250 is a phosphorylation of endogenous Mer inhibitor with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:15:28 ]
AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:11:21 ]
PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:08:40 ]
Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:05:15 ]
ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:02:10 ]
NVP-BGJ398(BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:59:04 ]
