Name | Repaglinide |
Synonyms | (S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid; Novonorm; Prandin |
MF | C27H36N2O4 |
MW | 452.59 |
CAS | 135062-02-1 |
Quality Standard | EP/USP |
Delivery Date | 7-12 days |
Application | Pharmaceutical raw materials |
Other name: 4-Ethoxycarbonyl-3-ethoxy phenyl acetic acid; (S)-(+)-2-Ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid; 2-ethoxy-4-[2-({3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl}amino)-2-oxoethyl]benzoic acid; 2-ethoxy-4-[2-({(1S)-3-methyl-1-[2-(piperidin-1-yl)phenyl]butyl}amino)-2-oxoethyl]benzoic acid
CAS NO.: 135062-02-1
MF: C27H36N2O4
MW: 452.5857
InChI: 1/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
Melting point: 129-130°C
Boiling point: 672.9°C at 760 mmHg
Flash point: 360.8°C
Density: 1.137g/cm3
Standard: USP/BP/CP/EP
Odor: odorless
Items | Specifications | Results |
Appearance | Off white crystalline powder | Off white crystalline powder |
Identification | Infared Absorption | Complies |
The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assay | complies | |
Specific rotation | Between -28.6°and -35.0°, measured at 20° | -32.8° |
Water | not more than 0.5% | 0.12% |
residue on ignition | not more than 0.2% | 0.11% |
Heavy metals | not more than 0.001% | complies |
related compounds by HPLC | Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5% | Fructose: 0.03% Compound A: 0.04% Total impurities: 0.07% |
Particle size | 90% less than 350 microns | complies |
Residual Solvent | Methylene Chloride not more than 250μg/g | not detected |
Acetone not mor than 2500μg/g | ||
Isopropanol not more than 5000μg/g | ||
Ethanenitrile not more than 400μg/g | ||
n-hexane not more than 290μg/g | ||
Ethyl Acetate not more than 2500μg/g | ||
Pyridine not more than 100μg/g | ||
Assay | Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis | 99.80% |
Conclustion | The material complies with respect to USP32 |
Wuhan Newbio Pharm-tech Co., Ltd. | |||||
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11 | 179324-69-7 | Bortezomib | 35 | 474645-27-7 | Monomethyl Auristatin E |
12 | 357336-20-0 | Brivaracetam | 36 | 63121-00-6 | Oxaliplatin |
13 | 842133-18-0 | Canagliflozin | 49 | 33069-62-4 | Paclitaxel |
14 | 928672-86-0 | Canagliflozin HemiHydrate | 37 | 137281-23-3 | Pemetrexed Disodium |
15 | 41575-94-4 | Carboplatin | 38 | 53123-88-9 | Rapamycin |
16 | 50935-04-1 | Carubicin | 50 | 135062-02-1 | Repaglinide |
17 | 288383-20-0 | Cediranib | 39 | 945667-22-1 | Saxagliptin Hydrate |
18 | 15663-27-1 | Cisplatin | 40 | 709031-78-7 | Saxagliptin Hydrochloride |
19 | 877399-52-5 | Crizotinib | 41 | 486460-32-6 | Sitagliptin |
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21 | 114977-28-5 | Docetaxel | 44 | 85622-93-1 | Temozolomide |
22 | 148408-66-6 | Docetaxel TriHydrate | 45 | 477600-75-2 | Tofacitinib |
23 | 25316-40-9 | Doxorubicin hydrochloride | 46 | 540737-29-9 | Tofacitinib Citrate |
24 | 133040-01-4 | Eprosartan | 47 | 170791-09-0 | Trityl Candesartan Cilexetil |
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synonyms: 3-ethoxy-4-(ethoxycarbonyl)benzeneaceticacid; ethyl 4-carboxymethyl-2-ethoxybenzoate; [3-ethoxy-4-(ethoxycarbonyl)phenyl]aceticacid; 3-ethoxy-4-ethoxycarbonylphenyl acetic acid; CAS No: 99469-99-5 Molecular formula: C13H16O5 Molecular weight: 252.26 Content: ≥99.0% ...