Crizotinib
Product Quick Detail
- FOB Price
- USD $160.00 / Piece
- Place Of Origin
- china
- Minimum Order
- 100
- Packaging
- 25kg
- Delivery
- 15 Days
Specifications
Quality Guarentee Small Molecular API Crizotinib
(CAS# 877399-52-5)
Chemical Information
(CAS# 877399-52-5)
Chemical Information
| Product Name | Crizotinib |
| Molecular Formula | C21H22Cl2FN5O |
| Molecular Weight | 450.34 |
| Storage | Store at -20°C |
| Targets | c-Met ALK |
| IC50 | 11 nM 24 nM |
Description
Crizotinib (PF-02341066) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley.
Application
The inhibitory effects of crizotinib on MP cells and SP cells were determined by colony formation assay. The IC50 value of crizotinib for MP cells was 21.3 nM. Of note, the SP cells showed no significant changes after crizotinib treatment. However, the SP cells showed a cell survival rate of 50.0±0.6% following a combined treatment of crizotinib (22.4 nM) and verapamil (500 µM), compared with 105.3±0.4% survival of SP cells treated with crizotinib (22.4 nM) alone. The growth curves obtained demonstrate that crizotinib inhibited the growth of SP and MP cells, and this inhibition was dependent on both concentration and time.
Tumorigenicity was examined using immune-deficient mice, into which SP or MP cells of LLC were subcutaneously transplanted. Nonsorted LLC cells formed xenografts in mice at 1x105 cells. Tumor size was significantly decreased in the crizotinib-treated LLC groups (225±29 mm3) compared to the untreated group (PBS: 834±41 mm3) by 40 days after treatment.
COA:
| Test Items | Specification | Results |
| Description | White to off white crystalline powder | Comply |
| Melting point | 166-170°C | 167.3-168.1°C |
| Identification | Positive reaction | Positive reaction |
| Related substances | â¤1.0% | 0.16% |
| Loss on drying | â¤0.5% | 0.06% |
| Residue on ignition | â¤0.1% | 0.02% |
| Chloride | â¤0.014% | <0.014 |
| Heavy Metals | â¤20ppm | <20ppm |
| Clarity of solution | Conform to standard | Complies |
| Microbial Limit | â¤20ppm | <20ppm |
| Assay | â¥99.0% | 99.12% |
FEATURED PRODUCT:
| Wuhan Newbio Pharm-tech Co., Ltd. | |||||
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| 8 | 1421373-66-1 | AZD-9291 (Mesylate) | 32 | 191732-72-6 | Lenalidomide |
| 9 | 123524-52-7 | Azelnidipine | 33 | 21672 | Methotrexate |
| 10 | 863031-21-4 | Azilsartan Medoxomil | 34 | 76144-81-5 | Mildronate |
| 11 | 179324-69-7 | Bortezomib | 35 | 474645-27-7 | Monomethyl Auristatin E |
| 12 | 357336-20-0 | Brivaracetam | 36 | 63121-00-6 | Oxaliplatin |
| 13 | 842133-18-0 | Canagliflozin | 49 | 33069-62-4 | Paclitaxel |
| 14 | 928672-86-0 | Canagliflozin HemiHydrate | 37 | 137281-23-3 | Pemetrexed Disodium |
| 15 | 41575-94-4 | Carboplatin | 38 | 53123-88-9 | Rapamycin |
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| 17 | 288383-20-0 | Cediranib | 39 | 945667-22-1 | Saxagliptin Hydrate |
| 18 | 15663-27-1 | Cisplatin | 40 | 709031-78-7 | Saxagliptin Hydrochloride |
| 19 | 877399-52-5 | Crizotinib | 41 | 486460-32-6 | Sitagliptin |
| 20 | 171500-79-1 | Dalbavancin | 42 | 654671-77-9 | Sitagliptin Phosphate Hydrate |
| 21 | 114977-28-5 | Docetaxel | 44 | 85622-93-1 | Temozolomide |
| 22 | 148408-66-6 | Docetaxel TriHydrate | 45 | 477600-75-2 | Tofacitinib |
| 23 | 25316-40-9 | Doxorubicin hydrochloride | 46 | 540737-29-9 | Tofacitinib Citrate |
| 24 | 133040-01-4 | Eprosartan | 47 | 170791-09-0 | Trityl Candesartan Cilexetil |
ABOUT DELIVERY:
#1 Products can be sent out within 24 hours after payment.
#2 Secure and discreet shipment.
#3 Various methods for your choice, like DHL/FedEx/SF-express.
OUR COMMITMENT:
#1 We are manufacturer with own factory and we sale this product at a best quality and low price.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
CONTACT US:
| Telephone | +86-027-87002705 |
| Mobile | +86-13277093700 |
| newbiopharmtech | |
| FaceBook Page | https://www.facebook.com/newbiopharma/ |
| Facebook Group | https://www.facebook.com/groups/1739616069613416/ |
| Website | http://www.newbiopharm.com/ |
| Online Store | http://biocar.en.made-in-china.com/ |
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- Country: China (Mainland)
- Business Type:
- Market:
- Founded Year:2015
- Address:
- Contact:Jason Edwards
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