Axitinib

FOB Price
USD $160.00 / Piece
Place Of Origin
china
Minimum Order
100
Packaging
25kg
Delivery
15 Days
Hot Sell Small Molecular API Axitinib
(CAS# 319460-85-0)

Chemical Information
Product Name Axitinib
Molecular Formula C22H18N4OS
Molecular Weight 386.47
Storage Store at -20°C
Targets VEGFR-1 VEGFR-2 VEGFR-3
IC50 1.2 nM 0.2 nM 0.1 to 0.3 nM

Description
Axitinib inhibited the phosphorylation of VEGFR-1, 2 and 3 with IC50 values of 1.2 nM, 0.2 nM and 0.1 to 0.3 nM in cells, respectively. In HUVEC cells, Axitinib inhibited VEGFR-2 stimulated cell survival with about 1000-fold selectivity against FGFR-1. Axitinib also significantly suppressed the phosphorylation of VEGF downstream signaling molecules including Akt, eNOS and ERK1/2. Besides that, axitinib inhibited VEGFR-2 phosphorylation with EC50 value of 0.49 nM in vivo. It delayed tumore growth of human xenograft tumors in mice such as M24met, HCT-116 and SN12C .

General tips For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months.
COA:
Item Requirements Results
Description White to off-white powder Complies
Identification
IR IR chromatograph Conforms to
the characteristic peak of R.S.
Complies
HPLC The retention time of the major
peak in the chromatogram
Conforms to the characteristic
peak of R.S.
Complies
Residue on ignition ≤0.20% 0.08%
Related substance
Total impurities ≤1.0% 0.16%
Single impurity ≤0.50% 0.04%
Loss on drying ≤1.0% 0.10%
Heavy Metal ≤20ppm Complies
Purity(HPLC) ≥99.0% 100.0%
Conclusion Meets the Requirements

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FEATURED PRODUCT:
Wuhan Newbio Pharm-tech Co., Ltd.
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2 154229-18-2 Abiraterone Acetate 26 183319-69-9 Erlotinib Hydrochloride
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TriHydrate
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13 842133-18-0 Canagliflozin 49 33069-62-4 Paclitaxel
14 928672-86-0 Canagliflozin HemiHydrate 37 137281-23-3 Pemetrexed Disodium
15 41575-94-4 Carboplatin 38 53123-88-9 Rapamycin
16 50935-04-1 Carubicin 50 135062-02-1 Repaglinide
17 288383-20-0 Cediranib 39 945667-22-1 Saxagliptin Hydrate
18 15663-27-1 Cisplatin 40 709031-78-7 Saxagliptin Hydrochloride
19 877399-52-5 Crizotinib 41 486460-32-6 Sitagliptin
20 171500-79-1 Dalbavancin 42 654671-77-9 Sitagliptin Phosphate Hydrate
21 114977-28-5 Docetaxel 44 85622-93-1 Temozolomide
22 148408-66-6 Docetaxel TriHydrate 45 477600-75-2 Tofacitinib
23 25316-40-9 Doxorubicin hydrochloride 46 540737-29-9 Tofacitinib Citrate
24 133040-01-4 Eprosartan 47 170791-09-0 Trityl Candesartan Cilexetil

ABOUT DELIVERY:
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#2 Secure and discreet shipment.
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​
OUR COMMITMENT:
#1 We are manufacturer with own factory and we sale this product at a best quality and low price.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
​
CONTACT US:
Telephone +86-027-87002705
Mobile +86-13277093700
newbiopharmtech
FaceBook Page https://www.facebook.com/newbiopharma/
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Website http://www.newbiopharm.com/
Online Store http://biocar.en.made-in-china.com/
​
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  • Country: China (Mainland)
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  • Founded Year:2015
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  • Contact:Jason Edwards
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Axitinib
Axitinib

Product Name: Axitinib Synonyms: AXITINIB;Benzamide, ...

y.uancheng.

Axitinib
Axitinib

中文名称: 阿西替尼 中文同义词: 阿西替尼;N-甲基-2-((3-((1E)-2-(吡啶-2-基)乙烯)-1H-吲唑-6-基)硫)苯甲酰胺;AXI锡IB;苯甲酰胺, N-甲基-2-[[3-[(1E)-2-(2-吡啶 ...

Hubei Yuancheng Saichuang Technology Co.