Erlotinib Hydrochloride
Product Quick Detail
- FOB Price
- USD $280.00 / Piece
- Place Of Origin
- Hubei, China
- Minimum Order
- 100
- Packaging
- Aluminum Foil Bags or Fiber Drum.
- Delivery
- 15 Days
Specifications
Small Molecular Erlotinib Hydrochloride
(CAS No.: 183319-69-9)
Chemical Information
Description
Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.
Erlotinib HCl (1 μM) induces apoptosis in DiFi humancolon cancer cells. Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM. Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells.
Application
Cells were treated with single dose of erlotinib (1 µM, 24 hours), The greatest cell death was observed in the Txt->OSI-774->media sequence, while the cells treated with the OSI-774->Txt->media sequence resumed proliferation by 72hrs post-treatment. Cleaved PARP and Caspase-3 were detected in the sequence of Txt->OSI-774, and with simultaneous treatment, but not in the sequence of OSI-774->Txt. Further, cleaved PARP and Caspase-3 persisted to 72hrs after the Txt->OSI-774 treatment. These data support the previous results on sub-G1 cells, and molecularly demonstrate an apoptotic response.
Erlotinib had significant dose-dependent efficacy. In the 100mg/kg group there was growth inhibition of 61%. The other groups had the following growth inhibition: 25mg/kg: 46%; 12.5mg/kg: 36%; 6.25mg/kg: 28%. There were no partial or complete regressions.
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#1 Pharmaceutical raw material,
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#3 Antibiotics or fine chemicals,
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(CAS No.: 183319-69-9)
Chemical Information
| Product Name | Erlotinib hydrochloride |
| Molecular Formula | C22H24ClN3O4 |
| Molecular Weight | 429.91 |
| Storage | Store at -20°C |
| Targets | HER1 EGFR |
| IC50 | 2 nM 2 nM |
| Erlotinib hydrochloride CAS 183319-69-9 | CAS 183319-69-9 | Brand: NEWBIO |
| MF C22H24ClN3O4 | EINECS:ND | |
| MW 429.9 | MOQ: 100grams | |
| Product Categories: | API;Molecular Targeted Antineoplastic;Heterocyclic Compounds;anti-neoplastic;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | |
| Usage | Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). It is marketed in the United States by Genentech and OSI Pharmaceuticals and elsewhere by Roche. | |
| Applications | Erlotinib hydrochloride , Pharmaceutical raw materials |
Description
Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM in cell-free assays, >1000-fold more sensitive for EGFR than human c-Src or v-Abl.
Erlotinib HCl (1 μM) induces apoptosis in DiFi humancolon cancer cells. Erlotinib inhibits growth of a panel of NSCLC cell lines including A549, H322, H3255, H358 H661, H1650, H1975, H1299, H596 with IC50 ranging from 29 nM to >20 μM. Erlotinib HCl(2 μM) significantly inhibits growth of AsPC-1 and BxPC-3 pancreatic cells.
Application
Cells were treated with single dose of erlotinib (1 µM, 24 hours), The greatest cell death was observed in the Txt->OSI-774->media sequence, while the cells treated with the OSI-774->Txt->media sequence resumed proliferation by 72hrs post-treatment. Cleaved PARP and Caspase-3 were detected in the sequence of Txt->OSI-774, and with simultaneous treatment, but not in the sequence of OSI-774->Txt. Further, cleaved PARP and Caspase-3 persisted to 72hrs after the Txt->OSI-774 treatment. These data support the previous results on sub-G1 cells, and molecularly demonstrate an apoptotic response.
Erlotinib had significant dose-dependent efficacy. In the 100mg/kg group there was growth inhibition of 61%. The other groups had the following growth inhibition: 25mg/kg: 46%; 12.5mg/kg: 36%; 6.25mg/kg: 28%. There were no partial or complete regressions.
FEATURED PRODUCT:
| Wuhan Newbio Pharm-tech Co., Ltd. | |||||
| S# | CAS No. | Product Name | S# | CAS No. | Product Name |
| 1 | 86639-52-3 | 7-Ethyl-10-Hydroxycamptothecin | 25 | 183321-74-6 | Erlotinib |
| 2 | 154229-18-2 | Abiraterone Acetate | 26 | 183319-69-9 | Erlotinib Hydrochloride |
| 3 | 50-76-0 | Actinomycin D | 27 | 159351-69-6 | Everolimus |
| 4 | 106941-25-7 | Adefovir | 28 | 56296-78-7 | Fluoxetine Hydrochloride |
| 5 | 850140-72-6 | Afatinib | 29 | 184475-55-6 | Gefitinib Hydrochloride |
| 6 | 330784-47-9 | Avanafil | 30 | 136572-09-3 | Irinotecan Hydrochloride TriHydrate |
| 7 | 319460-85-0 | Axitinib | 31 | 1441674-54-9 | Ledipasvir(Acetone) |
| 8 | 1421373-66-1 | AZD-9291 (Mesylate) | 32 | 191732-72-6 | Lenalidomide |
| 9 | 123524-52-7 | Azelnidipine | 33 | 21672 | Methotrexate |
| 10 | 863031-21-4 | Azilsartan Medoxomil | 34 | 76144-81-5 | Mildronate |
| 11 | 179324-69-7 | Bortezomib | 35 | 474645-27-7 | Monomethyl Auristatin E |
| 12 | 357336-20-0 | Brivaracetam | 36 | 63121-00-6 | Oxaliplatin |
| 13 | 842133-18-0 | Canagliflozin | 49 | 33069-62-4 | Paclitaxel |
| 14 | 928672-86-0 | Canagliflozin HemiHydrate | 37 | 137281-23-3 | Pemetrexed Disodium |
| 15 | 41575-94-4 | Carboplatin | 38 | 53123-88-9 | Rapamycin |
| 16 | 50935-04-1 | Carubicin | 50 | 135062-02-1 | Repaglinide |
| 17 | 288383-20-0 | Cediranib | 39 | 945667-22-1 | Saxagliptin Hydrate |
| 18 | 15663-27-1 | Cisplatin | 40 | 709031-78-7 | Saxagliptin Hydrochloride |
| 19 | 877399-52-5 | Crizotinib | 41 | 486460-32-6 | Sitagliptin |
| 20 | 171500-79-1 | Dalbavancin | 42 | 654671-77-9 | Sitagliptin Phosphate Hydrate |
| 21 | 114977-28-5 | Docetaxel | 44 | 85622-93-1 | Temozolomide |
| 22 | 148408-66-6 | Docetaxel TriHydrate | 45 | 477600-75-2 | Tofacitinib |
| 23 | 25316-40-9 | Doxorubicin hydrochloride | 46 | 540737-29-9 | Tofacitinib Citrate |
| 24 | 133040-01-4 | Eprosartan | 47 | 170791-09-0 | Trityl Candesartan Cilexetil |
ABOUT DELIVERY:
#1 Products can be sent out within 24 hours after payment.
#2 Secure and discreet shipment.
#3 Various methods for your choice, like DHL/FedEx/SF-express.
OUR COMMITMENT:
#1 We are manufacturer with own factory and we sale this product at a best quality and low price.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
CONTACT US:
| Telephone | +86-027-87002705 |
| Mobile | +86-13277093700 |
| newbiopharmtech | |
| FaceBook Page | https://www.facebook.com/newbiopharma/ |
| Facebook Group | https://www.facebook.com/groups/1739616069613416/ |
| Website | http://www.newbiopharm.com/ |
| Online Store | http://biocar.en.made-in-china.com/ |
If you want to source ...
#1 Pharmaceutical raw material,
#2 Oncology drug APIs,
#3 Antibiotics or fine chemicals,
We are a reliable manufacturer and supplier in China.
NEWBIO would like to ...
#1 We foucus on the high purity and high quality;
#2 We provide the raw materials at a good price;
#3 We have the best service and we are always there for you.
Please contact us for more infomation!!!
- Country: China (Mainland)
- Business Type:
- Market:
- Founded Year:2015
- Address:
- Contact:Jason Edwards
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