Cisplatin | CAS :15663-27-1 | Brand:NEWBIO |
MW: Cl2H6N2Pt | MSDS: Avaiable |
MF : 300.05
| Sample: Avaiable |
Category: Oncology drug | Min order: 10grams |
Quality standard:USP29 /EP5 | Place of Origin:China |
Introduction | Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors.Cisplatin is particularly effective against testicular cancer; the cure rate was improved from 10% to 85%. In addition, Cisplatin is used in Auger therapy. |
Character | Yellow or orange yellow crystals powder |
Applications | Pharmaceutical raw materials , Oncology drug |
Product Description
Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.
COA: Analysis Test | Specification | Result |
Description | white crystalline powder,odorless | Conforms |
Solubility | Easily soluble in water, unsoluble in ethanol | Conforms |
PH | 6.0~7.5 | 6.9 |
Solution clarity and color | solution should be clear and colorless | Conforms |
| 5'CMP 0.3% | 0.0001 |
Related substances | Simple impurity | 0.0003 |
| Total other impurity | 0.001 |
Chloride | 0.0005 | Conforms |
Ammonium | 0.0005 | Conforms |
Fe | 0.0001 | Conforms |
Phosphate | 0.001 | Conforms |
Loss on drying | â¤6.0% |
|
Heavy metals | 0.00002 | Conforms |
Arsenide | 0.000001 | Conforms |
Bacterial Endotoxins | 0.3EU/mg | Conforms |
Microbial Limit |
| Conforms |
Assay(on dried basis) | â¥98.0% | 0.988 |
Conclusion: The results conform with CP2010 |
Wuhan Newbio Pharm-tech Co., Ltd. |
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2 | 154229-18-2 | Abiraterone Acetate | 26 | 183319-69-9 | Erlotinib Hydrochloride |
3 | 50-76-0 | Actinomycin D | 27 | 159351-69-6 | Everolimus |
4 | 106941-25-7 | Adefovir | 28 | 56296-78-7 | Fluoxetine Hydrochloride |
5 | 850140-72-6 | Afatinib | 29 | 184475-55-6 | Gefitinib Hydrochloride |
6 | 330784-47-9 | Avanafil | 30 | 136572-09-3 | Irinotecan Hydrochloride TriHydrate |
7 | 319460-85-0 | Axitinib | 31 | 1441674-54-9 | Ledipasvir(Acetone) |
8 | 1421373-66-1 | AZD-9291 (Mesylate) | 32 | 191732-72-6 | Lenalidomide |
9 | 123524-52-7 | Azelnidipine | 33 | 21672 | Methotrexate |
10 | 863031-21-4 | Azilsartan Medoxomil | 34 | 76144-81-5 | Mildronate |
11 | 179324-69-7 | Bortezomib | 35 | 474645-27-7 | Monomethyl Auristatin E |
12 | 357336-20-0 | Brivaracetam | 36 | 63121-00-6 | Oxaliplatin |
13 | 842133-18-0 | Canagliflozin | 49 | 33069-62-4 | Paclitaxel |
14 | 928672-86-0 | Canagliflozin HemiHydrate | 37 | 137281-23-3 | Pemetrexed Disodium |
15 | 41575-94-4 | Carboplatin | 38 | 53123-88-9 | Rapamycin |
16 | 50935-04-1 | Carubicin | 50 | 135062-02-1 | Repaglinide |
17 | 288383-20-0 | Cediranib | 39 | 945667-22-1 | Saxagliptin Hydrate |
18 | 15663-27-1 | Cisplatin | 40 | 709031-78-7 | Saxagliptin Hydrochloride |
19 | 877399-52-5 | Crizotinib | 41 | 486460-32-6 | Sitagliptin |
20 | 171500-79-1 | Dalbavancin | 42 | 654671-77-9 | Sitagliptin Phosphate Hydrate |
21 | 114977-28-5 | Docetaxel | 44 | 85622-93-1 | Temozolomide |
22 | 148408-66-6 | Docetaxel TriHydrate | 45 | 477600-75-2 | Tofacitinib |
23 | 25316-40-9 | Doxorubicin hydrochloride | 46 | 540737-29-9 | Tofacitinib Citrate |
24 | 133040-01-4 | Eprosartan | 47 | 170791-09-0 | Trityl Candesartan Cilexetil |
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